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      Functional and Morphological Properties of Human Omental Resistance Vessels

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          Abstract

          We have examined the functional and morphological properties of arterial resistance vessels with lumen diameters about 200 µm from the human omentum. The vascular smooth muscle cells were circumferentially oriented and arranged in about 3 layers within the media. The cells, when held at a length where their contractile response was maximal, were 97 µm long and had a mean diameter of 3.9 µm. In response to maximum potassium stimulation the force developed per cell was 2.4 µN. The maximum response to norepinephrine (NE) was about 90% of the response to potassium, while the sensitivity to NE (NE-ED<sub>50</sub> = 0.4 µM) was about the same as the NE sensitivity reported for larger human vessels. The sensitivity to NE was unaffected by cocaine, while the response to potassium was unaffected by phentolamine. Fluorescence microscopy indicated that the vessels contained few adrenergic nerve terminals. These findings suggest that although the vessels are well supplied with alpha-receptors, the vessels are only of minor importance for sympathetic blood pressure control.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1981
          1981
          19 September 2008
          : 18
          : 6
          : 233-244
          Affiliations
          Biophysics Institute, Aarhus University, Aarhus, Denmark
          Article
          158357 Blood Vessels 1981;18:233–244
          10.1159/000158357
          7326433
          © 1981 S. Karger AG, Basel

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          Page count
          Pages: 12
          Categories
          Research Paper

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