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      A systematic review study of therapeutic effects of Matricaria recuitta chamomile (chamomile)

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          Abstract

          Introduction

          Matricaria recuitta chamomilla is a plant that grows and is cultivated in some parts of Iran. The aim of this study was to overview the therapeutic effects of this valuable plant. This systematic review was aimed to introduce Matricaria recuitta chamomile, its chemical compounds, and its traditional usages.

          Methods

          This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases. The initial search strategy identified about 87 references. In this study, 69 studies were accepted for further screening and met all our inclusion criteria [in English, full text, therapeutic effects of Matricaria recuitta chamomilla L and dated mainly from the year 1990 to 2016]. The search terms were “ Matricaria recuitta chamomilla L.,” “therapeutic properties,” “pharmacological effects.”

          Result

          It is commonly used for its antioxidant, antimicrobial, antidepressant, anti-inflammatory, antidiarrheal activities, angiogenesis activity, anticarcinogenic, hepatoprotective, and antidiabetic effects. Besides, it is beneficial for knee osteoarthritis, ulcerative colitis, premenstrual syndrome, and gastrointestinal disorders.

          Conclusion

          Matricaria recuitta chamomilla L. is widely used for therapeutic and nontherapeutic purposes that trigger its significant value. Various combinations and numerous medicinal properties of its extract, oil, and leaves demand further studies about other useful and unknown properties of this multipurpose plant.

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          Most cited references58

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          A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.).

          Jeffrey Blumberg, Susannah McKay (2006)
          Chamomile (Matricaria recutita L., Chamomilla recutita L., Matricaria chamomilla) is one of the most popular single ingredient herbal teas, or tisanes. Chamomile tea, brewed from dried flower heads, has been used traditionally for medicinal purposes. Evidence-based information regarding the bioactivity of this herb is presented. The main constituents of the flowers include several phenolic compounds, primarily the flavonoids apigenin, quercetin, patuletin, luteolin and their glucosides. The principal components of the essential oil extracted from the flowers are the terpenoids alpha-bisabolol and its oxides and azulenes, including chamazulene. Chamomile has moderate antioxidant and antimicrobial activities, and significant antiplatelet activity in vitro. Animal model studies indicate potent antiinflammatory action, some antimutagenic and cholesterol-lowering activities, as well as antispasmotic and anxiolytic effects. However, human studies are limited, and clinical trials examining the purported sedative properties of chamomile tea are absent. Adverse reactions to chamomile, consumed as a tisane or applied topically, have been reported among those with allergies to other plants in the daisy family, i.e. Asteraceae or Compositae.
          Article 0 comments Cited 147 times – based on 0 reviews     Review now
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            Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions.

            L. Miller, Daniel G. Miller (1998)
            Herbal medicinals are being used by an increasing number of patients who typically do not advise their clinicians of concomitant use. Known or potential drug-herb interactions exist and should be screened for. If used beyond 8 weeks, Echinacea could cause hepatotoxicity and therefore should not be used with other known hepatoxic drugs, such as anabolic steroids, amiodarone, methotrexate, and ketoconazole. However, Echinacea lacks the 1,2 saturated necrine ring associated with hepatoxicity of pyrrolizidine alkaloids. Nonsteroidal anti-inflammatory drugs may negate the usefulness of feverfew in the treatment of migraine headaches. Feverfew, garlic, Ginkgo, ginger, and ginseng may alter bleeding time and should not be used concomitantly with warfarin sodium. Additionally, ginseng may cause headache, tremulousness, and manic episodes in patients treated with phenelzine sulfate. Ginseng should also not be used with estrogens or corticosteroids because of possible additive effects. Since the mechanism of action of St John wort is uncertain, concomitant use with monoamine oxidase inhibitors and selective serotonin reuptake inhibitors is ill advised. Valerian should not be used concomitantly with barbiturates because excessive sedation may occur. Kyushin, licorice, plantain, uzara root, hawthorn, and ginseng may interfere with either digoxin pharmacodynamically or with digoxin monitoring. Evening primrose oil and borage should not be used with anticonvulsants because they may lower the seizure threshold. Shankapulshpi, an Ayurvedic preparation, may decrease phenytoin levels as well as diminish drug efficacy. Kava when used with alprazolam has resulted in coma. Immunostimulants (eg, Echinacea and zinc) should not be given with immunosuppressants (eg, corticosteroids and cyclosporine). Tannic acids present in some herbs (eg, St John wort and saw palmetto) may inhibit the absorption of iron. Kelp as a source of iodine may interfere with thyroid replacement therapies. Licorice can offset the pharmacological effect of spironolactone. Numerous herbs (eg, karela and ginseng) may affect blood glucose levels and should not be used in patients with diabetes mellitus.
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              Herbal medicine

              V. Kamboj, VP Kamboj, Kamboj … (2000)
              Article 0 comments Cited 54 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Electron Physician
                Journal ID (iso-abbrev): Electron Physician
                Journal ID (publisher-id): Electronic physician
                Title: Electronic Physician
                Publisher: Electronic physician
                ISSN (Electronic): 2008-5842
                Publication date Collection: September 2016
                Publication date (Electronic): 20 September 2016
                Volume: 8
                Issue: 9
                Pages: 3024-3031
                Affiliations
                [1 ]M.D., Gynecologist, Fellowship of Infertility, Assistant Professor, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
                [2 ]MD, Assistant Professor of Rheumatology and internal medicine, Department of Rheumatology, Internal Medicine, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran
                Author notes
                Corresponding author: Assistant Professor, Dr. Samira Alesaeidi. Department of Rheumatology, internal medicine, Amiralam hospital, Tehran University of Medical Sciences, Tehran, Iran. Tel: +98.9128884692, Fax: +98.32225456, Email: s-alesaeidi@ 123456sina.tums.ac.ir
                Article
                Publisher ID: epj-08-3024
                DOI: 10.19082/3024
                PMC ID: 5074766
                PubMed ID: 27790360
                SO-VID: f5b2b06b-50ac-431d-be51-ee6c0d774467
                Copyright © © 2016 The Authors
                License:

                This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

                History
                Date received : 26 April 2016
                Date accepted : 20 August 2016
                Categories
                Subject: Systematic Review

                Keywords: matricaria recuitta chamomilla l,phytochemicals,therapeutic effects,pharmacognosy,alternative and complementary medicine
                Data availability:
                Keywords: matricaria recuitta chamomilla l, phytochemicals, therapeutic effects, pharmacognosy, alternative and complementary medicine

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