Glacier runoff from the Yangtze River source region (YRSR), China, is estimated for the period 1961–2000 using a degree-day approach. In the investigation area, glacier runoff accounts for 11.0% of the total river runoff during the period 1961–2000. In the 1990s its contribution to river runoff rises to 17.0%. Due to the current rate of glacier decline, the impact of glacier runoff on river runoff has recently increased in the source region. Based on two different climate-change scenarios derived from ECHAM5/MPI-OM, future glacier runoff is assessed for the period 2001–50. In all climate-change scenarios, annual glacier runoff shows a significant increase due to intensified ice melting. There is an increase in glacier runoff during spring and early summer, yet a significant decrease in late summer. This study highlights the current and future impact of glacier runoff on river runoff in the YRSR.