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      Could vitamin D deficiency influence left heart ventricular geometry in youngsters with type 1 diabetes mellitus?

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          Abstract

          Background: Experimental and clinical studies have shown the cardio-protective, anti-inflammatory, and anti-atherosclerotic actions of vitamin D.

          Material and Methods: We aimed to investigate a possible correlation between vitamin D status and heart geometry using echocardiographic parameters of the left ventricle in youngsters with type 1 diabetes mellitus (T1D). Seventy-eight pediatric patients (aged 13.47 ± 2.86 years) with T1D of more than two years duration and 74 healthy controls (aged 12.04 ± 2.79 years) were enrolled in this case-control study. Anthropometric parameters were recorded, vitamin D and parathormone serum levels were measured, and trans-thoracic echocardiographic study was performed.

          Results: Vitamin D deficiency was found in 74 % T1D patients and in 72 % of the controls, while parathormone levels were normal in both groups. T1D patients presented significantly higher values of interventricular septal thickness at diastole (IVSD) compared to controls (0.76 ± 0.16 cm vs 0.71 ± 0.14 cm, p =0.043). All other echocardiographic parameters did not exhibit significant differences between patients and controls. The diastolic function of the left ventricle (LV) was normal in both groups. After sub-grouping, the participants according to the deficiency or not of vitamin D, only patients with T1D and low vitamin D levels had increased values of IVSD compared to controls (0.78 ± 0.17 vs 0.71 ± 0.14, p =0.008). Patients with T1D and normal vitamin D levels presented similar values of IVSD compared to controls (0.71 ± 0.12 vs 0.73 ± 0.15, p =NS).

          Conclusions: Children and adolescents with T1D and normal vitamin D levels do not exhibit changes in LV dimensions or diastolic function, except for increased IVSD, compared to controls. Larger and longitudinal studies are required to confirm and consolidate this finding. HIPPOKRATIA 2019, 23(1): 9-14.

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          Author and article information

          Journal
          Hippokratia
          Hippokratia
          Hippokratia
          SOCIETY OF "FRIENDS OF HIPPOKRATIA JOURNAL"
          1108-4189
          1790-8019
          Jan-Mar 2019
          : 23
          : 1
          : 9-14
          Affiliations
          4 th Department of Paediatrics, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece
          Author notes
          Kyriaki Papadopoulou-Legbelou, MD, PhD, Associate Professor in Paediatrics-Paediatric Cardiology, 4th Department of Pediatrics, Medical School, Aristotle University of Thessaloniki “Papageorgiou” General Hospital, Ring Road Nea Efkarpia, Thes-saloniki 56403, Greece, tel: +302310991463, fax: +302313323918 kelipap@ 123456gmail.com ; kpapadopoulou@ 123456auth.gr
          Article
          PMC7124876 PMC7124876 7124876 111540327
          7124876
          32256032
          f5beb85e-bbe4-4a7b-8101-3e5fe9bba3d0
          Copyright 2019, Hippokratio General Hospital of Thessaloniki
          History
          Categories
          Research Article

          adolescent,Vitamin D deficiency,diabetes type 1,echocardiography,child

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