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      Effect of aldehyde cross-linking on human dermal collagen implants in the rat.

      British journal of experimental pathology

      pharmacology, Animals, Cell Count, Collagen, Female, Formaldehyde, Glutaral, Graft Survival, Transplantation, Heterologous, drug effects, Humans, Male, Rats, Rats, Inbred Strains, Skin, analysis, Skin Transplantation, Aldehydes

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          Abstract

          The fate of s.c. implants of fibrous, trypsin-purified human dermal collagen and collagen cross-linked with formaldehyde and glutaraldehyde has been studied in rats. Dermal collagen, and untreated skin implants, underwent resorption associated with a pronounced round-cell reaction. While collagen implants cross-linked with solutions of 0.04% and 0.08% formaldehyde became reduced in size, those cross-linked with 1% formaldehyde and 0.01%, 0.02% and 0.04% glutaraldehyde, although undergoing some collagen remodelling, retained their original size over the 25-week period of study. At 5 weeks the aldehyde cross-linked implants showed their greatest cellularity, reaching a lower, more stable cell population by 18 weeks. More round cells were seen at 5 weeks, particularly after formaldehyde cross-linking, than a later times when few were present. The results indicate that aldehyde-stabilized preparations of heterograft dermal collagen could have applications in the repair of tissue defects in man.

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          6778496
          2041533

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