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      How Robust Are Laboratory Measures of Growth Hormone Status?

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          Biochemical assessment of growth hormone (GH) status is required in both suspected GH deficiency and GH excess. GH secretion can either be measured through investigation of the pituitary or by monitoring markers that change as a consequence of GH action on its target tissues. The two most widely used and, to date, best validated biochemical parameters are immunoassay measurement of either human GH (hGH) or insulin-like growth factor (IGF)-I. The fundamental difference between measurement of hGH and IGF-I is that the first reflects GH secretion while the second reflects GH action. However, because GH secretion is pulsatile in nature, random blood sampling for determination of hGH levels is only minimally informative. Analytical methods for measuring GH and IGF-I show considerable between-method variability. Since these parameters are used in establishing diagnoses and in monitoring GH-related diseases, the endocrinologist should be aware of the specifications and limitations of the analytical methods available.

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          Most cited references 13

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          Consensus Guidelines for the Diagnosis and Treatment of Growth Hormone (GH) Deficiency in Childhood and Adolescence: Summary Statement of the GH Research Society

           G. Society (2000)
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            Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human

             A Giustina (1998)
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              Consensus Guidelines for the Diagnosis and Treatment of Adults with Growth Hormone Deficiency: Summary Statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency

               ; (1998)

                Author and article information

                Horm Res Paediatr
                Hormone Research in Paediatrics
                S. Karger AG
                November 2005
                15 November 2005
                : 64
                : Suppl 2
                : 1-5
                aDivision of Clinical Endocrinology, Department of Medicine, Charité University – Medicine, Berlin; bNeuroendocrine Unit, Department of Medicine – Innenstadt, Ludwig Maximilians University, Munich, Germany
                87745 Horm Res 2005;64:1–5
                © 2005 S. Karger AG, Basel

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                Page count
                Figures: 1, Tables: 1, References: 21, Pages: 5
                Spectrum of GH Deficiency – Severe, Partial or Not at All?


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