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      ALOX12 gene polymorphisms and serum selenium status in elderly osteoporotic patients.

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          Abstract

          Osteoporosis is a systemic bone disease which leads to a reduction in bone mass. Many studies have shown that up to 80% of bone mineral density (BMD) variations are attributed to genetic factors. Arachidonate 12-lipoxygenase enzyme, encoded by the ALOX12 gene, produces lipid peroxides as reactive oxygen species (ROS), leading to oxidative stress and the development of osteoporosis. Selenium (Se) is incorporated into selenoproteins, which may reduce the risk of osteoporosis.

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          Author and article information

          Journal
          Adv Clin Exp Med
          Advances in clinical and experimental medicine : official organ Wroclaw Medical University
          Wroclaw Medical University
          1899-5276
          1899-5276
          Dec 2018
          : 27
          : 12
          Affiliations
          [1 ] Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Iran.
          [2 ] Department of Biochemistry and Nutrition, Faculty of Medicine, Zanjan University of Medical Sciences, Iran.
          [3 ] Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Iran.
          [4 ] Department of Biostatistics and Epidemiology, Faculty of Medicine, Zanjan University of Medical Sciences, Iran.
          [5 ] Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Iran.
          [6 ] Department of Internal Medicine, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Iran.
          [7 ] Department of Biochemistry, School of Medicine, Babol University of Medical Sciences, Iran.
          Article
          10.17219/acem/75689
          30277667
          f5f86654-5a54-464d-83a1-5de5b39deb9e
          History

          ALOX12,bone mineral density,osteoporosis,selenium,single nucleotide polymorphism

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