+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Reversal of Sex Roles in Genetic Female Mice by Disruption of Estrogen Receptor Gene

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Deficiency of normal estrogen receptor (ER) gene function led to behavioral change in female mice (ERKO females). Maternal behavior as measured by retrieving of pups was reduced. In some cases, pups were killed by the ERKO females, which was not seen in wild-type animals. Aggression toward other females was increased. Female-typical lordosis behavior was reduced for at least two reasons: less response to somatosensory stimuli on the hindquarters, as well as the fact that ERKO females were immediately treated as intruder males by resident ‘stud’ males and were thus attacked. In sum, disruption of the ER gene led to a pattern of hormonal and neural changes which caused the females to lose their normal female-typical behavior and to behave and be treated more like males.

          Related collections

          Author and article information

          S. Karger AG
          09 April 2008
          : 64
          : 6
          : 467-470
          aLaboratory of Neurobiology and Behavior, The Rockefeller University, New York, N.Y., bDepartments of Biochemistry and Child Health, University of Missouri-Columbia, Columbia, Mo., and cLaboratory of Reproductive and Developmental Toxicology, NIEHS, Research Triangle Park, N.C., USA
          127154 Neuroendocrinology 1996;64:467–470
          © 1996 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Rapid Communication


          Comment on this article