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      Mitochondrial form and function.

      1 , 1
      Nature
      Springer Science and Business Media LLC

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          Abstract

          Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells. Owing to their ability to produce ATP through respiration, they became a driving force in evolution. As an essential step in the process of eukaryotic evolution, the size of the mitochondrial chromosome was drastically reduced, and the behaviour of mitochondria within eukaryotic cells radically changed. Recent advances have revealed how the organelle's behaviour has evolved to allow the accurate transmission of its genome and to become responsive to the needs of the cell and its own dysfunction.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          1476-4687
          0028-0836
          Jan 16 2014
          : 505
          : 7483
          Affiliations
          [1 ] Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, California 95616, USA.
          Article
          nature12985 NIHMS590547
          10.1038/nature12985
          4075653
          24429632
          f5fe385b-59bb-4cb8-9988-a0a1e863e39f
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