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      A genetic risk score for thyroid peroxidase antibodies associates with clinical thyroid disease in community-based populations.

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          Abstract

          Antibodies against thyroid peroxidase (TPOAbs) are detected in 90% of all patients with Hashimoto thyroiditis, the most common cause of hypothyroidism. Hypothyroidism is associated with a range of adverse outcomes. The current knowledge of its genetic underpinnings is limited.

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          Author and article information

          Journal
          J. Clin. Endocrinol. Metab.
          The Journal of clinical endocrinology and metabolism
          The Endocrine Society
          1945-7197
          0021-972X
          May 2015
          : 100
          : 5
          Affiliations
          [1 ] Renal Division (U.T.S., Y.L., A.K.), Department of Medicine IV, Medical Center, University of Freiburg, 79106 Freiburg, Germany; Department of Internal Medicine and Rotterdam Thyroid Center (M.M., L.C., A.G.U., R.P.P.) and Department of Epidemiology (L.C., A.H.), Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands; Institute for Community Medicine (A.T., H.V.), Interfaculty Institute for Genetics and Functional Genomics (G.H.), and Institute of Clinical Chemistry and Laboratory Medicine (M.N.), University Medicine Greifswald, 17475 Greifswald, Germany; and Department of Epidemiology (N.D., E.S., A.K.), Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205.
          Article
          10.1210/jc.2014-4352
          4422885
          25719932
          f6019fdd-6208-48ab-b53a-8d18dd1bf04d
          History

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