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      Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries.

      Current Opinion in Microbiology
      Animals, Antigenic Variation, Trypanosoma brucei brucei, genetics, Variant Surface Glycoproteins, Trypanosoma

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          Abstract

          Antigenic variation allows African trypanosomes to develop chronic infections in mammalian hosts. This process results from the alternative occurrence of transcriptional switching and DNA recombination targeted to a telomeric locus that contains the gene of the variant antigen and is subjected to mono-allelic expression control. So far, the identification of mechanisms and factors involved still resists technological developments and genome sequencing.

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          Author and article information

          Journal
          15288623
          10.1016/j.mib.2004.05.001

          Chemistry
          Animals,Antigenic Variation,Trypanosoma brucei brucei,genetics,Variant Surface Glycoproteins, Trypanosoma

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