Tumor formation and antitumor immunity; the overlooked significance of histamine.

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Abstract

HA is a biogenic amine, widely distributed throughout the body. Given the observations that HA, the decarboxylated amino acid histidine, can be induced and made available in an unstored, diffusible form in tissues undergoing rapid growth (such as tumors and regenerating tissues), it could have a role in antitumor response beyond the well-studied inflammatory and allergic responses.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Leukoc. Biol.

Title: Journal of leukocyte biology

Publisher: Society for Leukocyte Biology

ISSN (Electronic): 1938-3673

ISSN (Print): 0741-5400

Publication date (Electronic): Aug 2014

Volume: 96

Issue: 2

Affiliations

[1 ] Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary afalus@gmail.com.

[2 ] Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary.

Article

Publisher Item ID: jlb.3RI0413-217RR

DOI: 10.1189/jlb.3RI0413-217RR

PubMed ID: 24904001

SO-VID: f611c528-df8c-4e2b-855c-7abc3b320b36

History

Keywords: regulation,cancer,immune response,biogenic amine

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Keywords: regulation, cancer, immune response, biogenic amine

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