Blog
About

8
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter.

      The FASEB Journal

      physiology, ATP-Binding Cassette Transporters, Amino Acid Substitution, Antigens, CD4, genetics, CD4-Positive T-Lymphocytes, Flow Cytometry, Genes, MDR, HIV Envelope Protein gp41, HIV-1, pathogenicity, HeLa Cells, Humans, Leukemia, T-Cell, Life Cycle Stages, P-Glycoprotein, Point Mutation, Receptors, CXCR4, Transfection, Tumor Cells, Cultured, Virus Replication

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The MDR1 multidrug transporter P-gp (P-glycoprotein) is an efflux pump that extrudes diverse hydrophobic drugs and peptides from cells. Since the entry of HIV-1 into cells involves an initial interaction of the viral gp41 hydrophobic peptide with the plasma membrane, a potential effect of P-gp on HIV-1 infectivity was explored. Virus production was greatly decreased when P-gp was overexpressed at the surface of a continuous CD4(+) human T-leukemic cell line (12D7) infected with HIV-1(NL4-3), a T-tropic molecular clone of HIV-1. P-gp overexpression did not significantly alter the surface expression or distribution of either the HIV-1 receptor CD4 or the coreceptor CXCR4. Reduction of HIV-1 infectivity in P-gp-expressing cells occurred both during the fusion of viral and plasma membranes and at subsequent step(s) in the HIV-1 life cycle.

          Related collections

          Author and article information

          Journal
          10698967

          Comments

          Comment on this article