Why was the cohort set up?
Population ageing is affecting low- and middle-income countries, with absolute and
relative numbers of older adults increasing quickly across the globe. This demographic
transition is accompanied by a health transition, driven by changing habits and lifestyles,
where non-communicable diseases are becoming the major cause of morbidity. Dementia
is strongly associated with age and is one of the main contributors to dependence
and disability. It has been estimated that there are nearly 47 million people currently
living with dementia, most of whom live in low- and middle-income countries (LMICs).
The title of the 10/66 Dementia Research Group (DRG) reflects the fact that, when
the group was formed in 1998, less than 10% of population-based research on dementia
had been carried out in developing countries although two-thirds of those affected
lived in those settings.
1
The 10/66 DRG research programme was developed to address this inequity, quantifying
dementia prevalence, incidence and impact across Latin American countries, China and
India, using a validated and common methodology. However, given that this was a population
cohort, the scope of the research was much broader than this—entailing a comprehensive
enquiry into health (common and burdensome chronic diseases, disability and health
service utilization), and social aspects of ageing (socioeconomic status, social protection,
needs for care and care arrangements).
Fundamental methodological issues, in particular the development, calibration and
validation of culture- and education-fair dementia diagnosis, and care arrangements
for care-dependent older people, were addressed in pilot investigations in 26 centres
from 16 low- and middle-income countries in Latin America and the Caribbean, Africa,
India, Russia, China and South East Asia (1999–2001).
2–5
The protocols for the 10/66 DRG baseline surveys and incidence phase surveys have
already been described in detail in a previous publication.
6
The purpose of this paper is to describe in more detail the resources created through
these completed surveys, together with findings from the research completed to date
and further plans for development of this resource.
Where is it located, who set it up and how has it been funded?
The 10/66 DRG is coordinated from London, within the Centre for Global Mental Health
at King’s College London, with a network of centres each led by a local principal
investigator. The 10/66 DRG’s research has been funded by the Wellcome Trust Health
Consequences of Population Change Programme (GR066133—Prevalence phase in Cuba and
Brazil; GR08002—Incidence phase in Peru, Mexico, Cuba, Dominican Republic, Venezuela
and China), World Health Organization (India, Dominican Republic and China), the US
Alzheimer’s Association (IIRG–04–1286—Peru and Mexico), FONACIT/ CDCH/ UCV (Venezuela),
and Puerto Rico Legislature (data collection in Puerto Rico) and Pfizer Co., USA (blood
sample collection in Puerto Rico). The new cohort is funded by a European Research
Council Advanced Grant (340755). The Rockefeller Foundation supported our dissemination
strategy meeting at their Bellagio Centre. Alzheimer Disease International (ADI) has
provided support for networking and infrastructure.
Who is in the cohort?
The 10/66 cohort is a population cohort comprising in principle all older residents
aged 65 years and over, living in 11 geographically defined urban and rural catchment
area sites in eight low- and middle-income countries. The selection of catchment areas
for the baseline phase of the survey was purposive, based upon their accessibility,
their use in the past as field sites for community or population research and the
existence of or potential for development of good relationships between the local
research groups and community stakeholders. Urban sites were selected to comprise
mixed or mainly lower socioeconomic status households; exclusively high-income or
professional districts were excluded. Urban sites were located in Cuba (one catchment
area comprising sites is Havana and Matanzas), Dominican Republic (Santo Domingo),
Puerto Rico (Bayamon), Venezuela (Caracas), Peru (Lima), Mexico (Mexico City), China
(Xicheng, Beijing province) and India (Chennai). Rural sites, selected to be remote
from major population centres, with low-density population and with agriculture and
related trades as the main local employment, were located in Peru (Canete Province),
Mexico (Morelos State) and China (Daxing, Beijing Province). The centre and site characteristics
are summarized in Figure 1. The baseline phase was conducted for all centres between
2004 and 2006, with the exception of Puerto Rico where baseline data were collected
between 2007 and 2010 (Figure 2). Mapping of the catchment areas was carried out within
specified boundaries, and households were allocated household identification numbers.
Enumeration was carried out by door-knocking all households in the catchment area
to identify potentially eligible participants (those aged 65 years or over on a census
date) who were then allocated participant identification numbers. These are linked
to names and addresses in secure databases held in London. Participants’ ages were
confirmed during the interview. Information about the age and sex of all other co-residents
was also recorded. After verifying eligibility, written consent was obtained from
participants or next of kin if the individual lacked capacity. Oral consent, witnessed
in writing by someone literate, was taken from illiterate participants. An overall
sample of 2000 per country would allow estimation of a typical dementia prevalence
of 4.5% with a precision of ± 0.9%, and rural and urban samples of 1000 each would
allow estimation of the same prevalence with a precision of ± 1.2%. A sample size
of around 2000 individuals for each country was achieved and the response rate was
excellent in most catchment areas, with a range of 72 % to 98% by site, and an average
across sites of 86% (Table 1).
Table 1.
Baseline sample socio-demographic characteristics and response rate by study centre
Cuba (%)
Dominican Republic (%)
Puerto Rico (%)
Peru urban (%)
Peru rural (%)
Venezuela (%)
Mexico urban (%)
Mexico rural (%)
China urban (%)
China rural (%)
India urban (%)
Participants (n)
2813
2011
2009
1381
552
1965
1003
1000
1160
1002
1005
Response rate (%)
94
95
93
80
88
80
84
86
74
96
72
Women
1836 (65.3)
1325 (66.0)
1347 (67.3)
888 (64.3)
295 (53.4)
1226 (63.5)
666 (66.40)
602 (60.20)
661 (57.0)
556 (55.49)
571 (57.7)
Age (years)
65–69
715 (25.5)
533 (26.5)
414 (20.6)
375 (27.2)
179 (32.4)
839 (42.8)
245 (24.4)
299 (29.9)
316 (27.2)
383 (38.2)
415 (41.5)
70–74
747 (26.6)
520 (25.9)
456 (22.7)
352 (25.5)
141 (25.5)
469 (23.9)
329 (32.8)
252 (25.2)
362 (31.2)
296 (29.5)
318 (31.8)
75–79
618 (22.0)
397 (19.7)
483 (24.0)
298 (21.6)
101 (18.3)
345 (17.6)
205 (20.5)
221 (22.1)
254 (21.9)
202 (20.2)
144 (14.4)
≥ 80
726 (25.9)
561 (27.9)
656 (32.6)
355 (25.7)
131 (23.7)
308 (15.7)
223 (22.3)
228 (22.8)
228 (19.7)
121 (12.1)
124 (12.4)
Marital status
Never married
262 (9.3)
139 (7.0)
123 (6.1)
145 (10.6)
68 (12.3)
189 (9.8)
63 (6.3)
42 (4.2)
3 (0.3)
22 (2.2)
21 (2.1)
Married/cohabiting
1199 (42.8)
586 (29.4)
967 (48.3)
784 (57.2)
308 (55.9)
921 (48.0)
470 (46.9)
538 (53.8)
829 (71.5)
585 (58.4)
523 (52.2)
Widowed
896 (31.9)
806 (40.4)
672 (33.6)
367 (26.8)
157 (28.5)
549 (28.6)
395 (39.4)
371 (37.1)
326 (28.1)
394 (39.3)
426 (42.5)
Divorced/separated
448 (16.0)
465 (23.3)
240 (12.0)
75 (5.5)
18 (3.3)
261 (13.6)
75 (7.5)
48 (4.8)
2 (0.2)
1 (0.1)
32 (3.2)
Education
None
73 (2.6)
392 (19.7)
72 (3.6)
37 (2.7)
84 (15.4)
156 (8.1)
227 (22.6)
327 (32.7)
232 (20.0)
579 (57.8)
428 (42.7)
Minimal
619 (22.1)
1022 (51.3)
389 (19.4)
90 (6.5)
141 (25.9)
445 (23.1)
354 (35.3)
510 (51.0)
153 (13.2)
114 (11.4)
234 (23.3)
Completed primary
937 (33.4)
370 (18.6)
415 (20.7)
460 (33.5)
267 (49.1)
965 (50.1)
229 (22.8)
122 (12.2)
303 (26.1)
259 (25.8)
212 (21.1)
Completed secondary
705 (25.1)
135 (6.8)
713 (35.5)
481 (35.0)
36 (6.6)
266 (13.8)
99 (9.9)
25 (2.5)
335 (28.9)
45 (4.5)
87 (8.7)
Tertiary
471 (17.0)
73 (3.7)
410 (20.4)
305 (22.2)
16 (2.9)
93 (4.8)
94 (9.4)
16 (1.6)
137 (11.8)
5 (0.5)
42 (4.2)
Number of assets
0–2
27 (1.0)
136 (6.8)
4 (0.2)
5 (0.4)
38 (6.9)
39 (2.0)
13 (1.3)
213 (21.3)
0
15 (1.5)
132 (13.2)
3–5
957 (34.1)
951 (47.4)
38 (1.9)
61 (4.4)
343 (62.1)
9 (0.5)
150 (15.0)
518 (51.8)
604 (52.1)
374 (37.3)
620 (61.9)
6–7
1821 (64.9)
919 (45.8)
1967 (97.9)
1315 (95.2)
171 (31.0)
1917 (97.6)
840 (83.7)
269 (26.9)
555 (47.9)
613 (61.2)
249 (24.9)
Occupation
Professional
1027 (38.8)
333 (16.6)
69 (8.3)
613 (45.5)
51 (9.3)
609 (34.0)
208 (20.7)
30 (3.0)
624 (54.1)
40 (4.0)
139 (14.9)
Trade
378 (14.3)
264 (13.2)
188 (22.7)
266 (19.7)
37 (6.7)
429 (23.9)
171 (17.0)
50 (5.0)
56 (4.9)
2 (0.2)
131 (14.1)
Semi-skilled
759 (28.7)
751 (37.5)
62 (7.5)
378 (28.0)
104 (18.9)
662 (36.9)
318 (31.7)
300 (30.0)
374 (32.4)
16 (1.6)
324 (34.8)
Labourer
469 (17.7)
640 (31.9)
3 (0.4)
22 (1.6)
29 (5.3)
77 (4.3)
257 (25.6)
440 (44.0)
96 (8.3)
16 (1.6)
224 (24.1)
Agricultural worker
203 (7.7)
15 (0.7)
507 (61.7)
69 (5.1)
330 (59.9)
16 (0.9)
49 (4.9)
180 (18.0)
3 (0.3)
928 (92.6)
112 (12.0)
Food insecurity
Yes
137 (4.9)
240 (12.1)
32 (1.6)
63 (4.6)
74 (13.5)
111 (6.0)
39 (3.9)
85 (8.6)
0 (0)
12 (1.2)
207 (20.8)
Living arrangements
Alone
250 (8.8)
254 (12.6)
472 (23.5)
45 (3.3)
44 (8.0)
61 (3.1)
106 (10.6)
112 (11.2)
54 (4.7)
49 (4.9)
44 (4.4)
With spouse
426 (15.1)
135 (6.7)
666 (33.2)
126 (9.1)
59 (10.7)
135 (6.9)
151 (15.1)
156 (15.6)
415 (35.8)
140 (14.0)
194 (19.4)
With adult children
1340 (47.6)
963 (47.9)
288 (14.3)
890 (64.4)
326 (59.1)
1578 (80.3)
565 (56.3)
523 (52.3)
446 (38.4)
679 (67.8)
719 (71.5)
Smoking status
Never
1612 (54.9)
1049 (52.2)
1454 (72.6)
1119 (81.4)
482 (87.5)
1061 (55.8)
648 (64.6)
729 (72.9)
875 (75.4)
666 (66.5)
730 (73.2)
Ex-smoker
759 (25.8)
711 (35.4)
444 (22.2)
201 (14.6)
55 (10.0)
624 (32.8)
246 (24.5)
200 (20.0)
92 (7.9)
31 (3.1)
86 (8.6)
Current
565 (19.2)
249 (12.4)
104 (5.2)
54 (3.9)
14 (2.5)
215 (11.3)
109 (10.9)
71 (7.1)
193 (16.6)
305 (30.4)
181 (18.2)
Figure 1
Distribution of the 10/66 centres. Countries in purple contain both rural and urban
centres, whereas countries in orange only have urban centres. The black dots represent
the catchment areas within each country. The centres are the following: China (Beijing
and Daxing), Cuba (Havana/Matanzas), Dominican Republic (Santo Domingo), India (Chennai),
Mexico (Mexico City and Morelos/Hidalgo), Peru (Lima and Canete), Puerto Rico (San
Juan) and Venezuela (Caracas).
Figure 2
Cohort diagram of the baseline and follow-up surveys; 2nd wave numbers refer to number
of people with a determined vital status.
The completed cohort resource
The cohort at baseline, with respect to vital status ascertained through to March
2014, comprised 15 901 participants at risk (Table 1; and Supplementary Table 1, available
as Supplementary data at IJE online). The median follow-up period ranged from 2.8
to 5.0 years by site, with a total of 53 872 person-years of observation. The vital
status of 13 936 participants (87.7%) was determined, with 2602 deaths occurring during
the follow-up period, for which 2436 verbal autopsy interviews were completed. The
proportion deceased at follow-up was higher in China, Dominican Republic and Cuba
than in other countries (in part a function of the longer follow-up interval in those
sites). With respect to the incidence of dementia (further excluding India, where
dementia-free participants were not followed up), 14 896 participants were interviewed
at baseline, 13 483 free of dementia; 9322 (69.1%) were re-interviewed, contributing
42 698 person-years of follow-up.
How often have they been followed up?
Participants of the baseline assessment were traced and followed up between 2007 and
2010 in the China, India (mortality only), Cuba, Dominican Republic, Mexico, Peru
and Venezuela sites, and between 2012 and 2013 in Puerto Rico. In India, all those
with mild cognitive impairment, ‘cognitive impairment no dementia’ (CIND) or dementia
at baseline completed the full incidence phase protocol, to determine the predictive
validity of baseline dementia diagnosis.
7
A mortality sweep was carried out on the full baseline cohort to determine vital status,
date of death of those deceased and a verbal autopsy on those deceased.
8
Subsequent to the baseline and incidence waves, the 10/66 INDEP sub-study has been
completed,
9
a nested study of households in Peru, Mexico and China, characteriszd as ‘incident
care’, ‘chronic care’ or ‘no care’, depending upon the needs for care of older residents.
This focuses on the economic and social functioning of the household as a whole. A
third full wave of assessment using an extended form of the basic 10/66 survey has
recently been planned and funded for Cuba, Dominican Republic, Puerto Rico, Mexico,
Peru, Venezuela and China, which will take place approximately 10 years on from the
original baseline surveys (2015–16).This will be a new prevalence sweep, with renewed
-door-knocking of the original catchment areas to generate a new representative prevalence
sample of all those aged 65 years and over, including those that have aged to 65 years
or over since the first prevalence wave, and in-migrants. Participants of the original
baseline survey will be traced and have their vital status ascertained, and be re-interviewed
where possible even if migrated out of the area.
What has been measured?
The same cross-culturally validated assessment was carried out across each centre,
during the baseline and follow-up phase of the study. All participants underwent a
comprehensive interview, including a structured interview, a physical examination
and an informant interview. Key informants were selected by interviewers on the basis
of who knew the old person best and could give the clearest and most detailed account
of their current circumstances. Co-residents and family members were prioritized unless
others were clearly better qualified. The main criterion for selection in case of
several co-resident family members was time spent with the older person. In cases
where the older person needed care, then the main caregiver was selected. However,
if the main caregiver was paid, the main organizational caregiver was selected instead.
Each full assessment, which lasted between 2 and 3 h, was translated, back-translated
and adapted as necessary into the different languages for each centre (Table 2).
Table 2.
Measurements in the different waves of studies. WHODAS (World Health Organization
Disability Assessment Schedule), DEMQOL (Dementia Quality Of Life Questionnaire),
CSI’D’ (Community Screening Instrument for Dementia), HAS (History and Aetiology Schedule),
NPI (Neuropsychiatric Inventory), GMS (Geriatric Mental State Examination)
Baseline
Follow-up
3rd wave/refreshment cohort
Household assessment
x
x
x
Age ascertainment
x
x
Household information
x
x
x
Number of assets
x
x
x
Participant interview
x
x
x
Early-life events
x
x
x
Current circumstances
x
x
x
Social network
x
x
x
Socioeconomic status
x
x
x
Health (including pain and impairments)
x
x
x
Disability (WHODAS-II) and dependence
x
x
x
Reproductive health
x
x
x
Behaviour and lifestyles
x
x
x
Use of health services
x
x
x
Quality of life (DEMQOL)
x
x
Cognitive functioning
CSI’D’
x
x
x
10-word list-learning test
x
x
x
Mental health (GMS – version B3)
x
x
x
Clinical examination
Neurological assessment (NEUROEX)
x
x
x
Physical assessment (anthropometry, pulse/blood pressure)
x
x
x
Stroke assessment
x
Advanced frailty assessment
x
Biological assessments
Haematological tests, full blood count (haemoglobin, haematocrit, differential, MCV,
MCH, MCHC)
x
x
x
(some centres)
(some centres)
Biochemical tests (fasting glucose, fasting total cholesterol and sub-fractions, triglyceride,
albumin, total protein)
x
x
x
(some centres)
(some centres)
Genotyping (ApoE)
x
x
x
(some centres)
(some centres)
Metabolic syndrome according to NCEP-ATP III criteria
x
x
x
(some centres)
(some centres)
Age-related decline biomarkers (cytokines, telomeres, CRP, testosterone, SHBG)
x
(nested-cohort)
a) Informant interview
Background information on informant
x
x
x
Caregiver questionnaire
x
x
x
CSI’D’ informant section
x
x
x
HAS-D
x
x
x
Behavioural and Psychological Symptoms of Dementia (NPI)
x
x
x
Participants background info
a
x
x
x
DEMQOL
x
x
Verbal autopsy
x
x
aAdministered when the participant is too demented or otherwise unable to answer the
questions reliably.
Socio-demographics
Information on age, sex, marital status, level of education (none; some, but did not
complete primary; completed primary; completed secondary; completed tertiary or further
education), household assets and household composition was assessed by a standard
socio-demographic questionnaire.
Health
For some conditions, health status was assessed using self-reported diagnoses, in
response to the question ‘has a doctor ever told you that you suffered from’: stroke,
diabetes, hypertension, heart disease (and hyperlipidaemia, at follow-up only), TB,
malaria or cysticercosis, and treatments for these conditions. Directly assessed diagnoses
included: (i) Dementia, ascertained according to the cross-culturally validated 10/66
dementia diagnosis algorithm
3
and the DSM-IV dementia criterion
10
after cognitive testing, clinical and informant interview; (ii) Depression according
to ICD-10 criteria and EURO-D scale scores, and syndromal levels of anxiety and psychosis
ascertained using the structured Geriatric Mental State clinical interview (GMS);
11–13
(iii) Hypertension according to European Society of Hypertension criteria (systolic
blood pressure > = 140 mmHg and/or diastolic blood pressure > = 95 mmHg, and/or a
positive answer to the question ‘have you ever been told by a doctor that you have
hypertension?’); (iv) Chronic Obstructive Pulmonary Disease (COPD) diagnosed in those
who responded ‘yes’ to the question ‘do you usually cough up phlegm from your chest
first thing in the morning?’ and whose answer to the question ‘for how many months
of the year does this usually happen?’ was 3 months or more.
Self-rated overall health and physical impairments (including eyesight problems; stomach
or intestine problems; arthritis or rheumatism; heart problems; hearing difficulties
or deafness etc.) were also assessed. Impairments were rated as present if they interfered
with activities ‘a little’ or ‘a lot’, as opposed to ‘not at all’.
14
Women’s reproductive history (menarche, menopause and parity) was also assessed. The
informant rated the presence and severity of any behavioural and psychological symptoms
(Neuropsychiatric Inventory Questionnaire -NPI-Q).
15
Finally, a physical examination was carried out comprising pulse and blood pressure,
height, leg length, skull, arm, waist and hip circumference and a structured neurological
examination (NEUROEX).
6
At follow-up only, weight and calf circumference were also assessed.
Impacts of health
Disability. Disability was measured using the 12-item World Health Organization Disability
Assessment Schedule version 2.0 (WHODAS 2.0). The WHODAS 2.0 has high internal consistency,
moderate to good test-retest reliability and good concurrent validity in many different
chronic disease clinical populations.
16–18
Dependence. The interviewer administered open-ended questions to the key informant,
to ascertain needs for care. The interviewer then coded whether the participant required
no care, care some of the time or care much of the time. This coding was based upon
the interviewer’s perception of needs for care, independently of whether these were
routinely met. Conditionally upon the presence of needs for care, we further assessed:
(i) Practical impact—contact time between caregiver and cared-for person
19
and time spent by the caregiver in the past 24 h in specific caregiving activities;
20
(ii) Caregiver perceived strain—the Zarit Burden Interview (ZBI)
21
,
22
with 22 items that assess the caregiver’s appraisal of the impact their involvement
has had on their lives.
Health service utilization was assessed using the Client Service Receipt Inventory,
23
a comprehensive assessment of direct and indirect economic costs for mental health
services, adapted for use in the developing world.
24
Help-seeking, specifically for symptoms and signs of dementia, was assessed at follow-up
only.
Risk exposures
Specific dementia risk factors (e.g. head injury with loss of consciousness, family
history of dementia) and broader lifestyle and cardiovascular risk factors including
alcohol use (volume and frequency currently and before the age of 60), lifetime smoking
(including pack-year calculation) and diet and exercise levels now and in earlier
life, were also assessed.
Biological samples
Fasting blood samples were collected in a subset of seven Latin American sites (Cuba,
Dominican Republic, Venezuela, Puerto Rico, urban Peru, and urban and rural Mexico),
for which we are also able to report the prevalence of undiagnosed diabetes and the
extent of control among diagnosed cases. We collected fluoride oxalate, EDTA and clot
samples. Haematological and biochemical analyses were carried out in local laboratories.
DNA was extracted to create a resource for genotyping. The range of assays carried
out varied among sites, depending on feasibility and funding (see Table 2; and Supplementary
Table2, available as Supplementary data at IJE online).
Overall, 9178 blood samples were collected. By site, the numbers and proportions providing
samples were: Cuba (2355, 80.4% of those participating in the survey), Dominican Republic
(1483, 73.8%), Puerto Rico (1584, 78.8%), Venezuela (1284, 65.3%), urban Peru (755,
54.7%), urban Mexico (822, 82.0%) and rural Mexico (895, 89.5%). There were few differences
in baseline characteristics of those who did and did not provide samples (Supplementary
Table 3, available as Supplementary data at IJE online), and those differences were
generally of small effect, other than in the urban Peru site where the more affluent
and better educated, but also those with more physical impairments, were more likely
to give blood samples.
The new third-wave prevalence survey will include an extended assessment of health
status, including spirometry, body mass index (BMI), visual acuity, grip strength
and hearing impairment. Moreover, a nested cohort of 300 individuals (150 with a high
risk of incident dependence and 150 without) will be identified and extensive laboratory
testing of frailty biomarkers carried out. This sub-group will be followed up 18 months
later to re-assess vital status, needs for care, disability, cognitive function and
significant health life events in the intervening period.
What has it found? Key findings and publications
Evidence on the construct and predictive validity of key measures has been further
strengthened. Norms for the cognitive tests indicate effects of age and education,
and a modest effect of culture upon the cognitive tests (10-word delayed recall and
CSI-D COGSCORE) that form the core of our 10/66 dementia diagnosis.
25
Our confidence in the validity of the 10/66 dementia diagnosis has been bolstered
by the demonstration, in Cuba, that it agreed better with Cuban clinician diagnoses
than did the DSM-IV computerzsed algorithm, which missed many recent-onset and mild
cases.
10
Across the cohort, levels of disability were similar for 10/66 dementia cases regardless
of whether they were confirmed as cases by the DSM-IV dementia algorithm.
26
Crucially, in urban India where the disparity between the prevalence of 10/66 dementia
and DSM-IV dementia was greatest, those with 10/66 dementia had a markedly elevated
mortality rate, and survivors showed clear evidence of clinical progression and increased
needs for care. Only one ‘case’ had unambiguously improved. Cognitive function had
deteriorated and disability increased to a much greater extent than among those with
CIND. Hence, the strong predictive validity of the 10/66 dementia diagnosis is consistent
with a lack of sensitivity of the DSM-IV criteria to mild-to-moderate cases, which
may underestimate prevalence in less developed regions. Regarding the WHODAS 2.0 disability
assessment scale, in the 10/66 DRG population-based survey samples strong internal
consistency and high factor loadings for the one-factor solution supported unidimensionality,
and the WHODAS 2.0 was found to be a ‘strong’ Mokken scale in all sites.
27
Morbidity in the baseline surveys of the cohort has been described in detail, with
publications on the prevalence of dementia,
26
mild cognitive impairment,
28
mental disorder,
29–32
sleep disorder,
33
hypertension,
34
stroke,
35
anaemia,
36
head injury
37
and dependence
38
(Table 3). Prevalence of most chronic disorders, including dementia, is similar to
that in high-income countries for urban settings in Latin America and China, and somewhat
lower in rural settings and in India. Detailed country reports delineate the impact
of population ageing and the epidemiological transition on patterns of chronic disease
morbidity and needs for care in Cuba,
39
Dominican Republic
40
and China.
41
The independent impact of different chronic diseases and frailty
42
on disability,
43
dependence,
38
co-resident psychological morbidity,
44
service utilization
24
and costs,
45
indicating a predominant contribution of disorders of the brain and mind (dementia,
stroke and depression) to disability, dependence and costs, but an inverse association
between dementia and healthcare service utilization.
Table 3.
Morbidity at baseline across sites, n (%)
Cuba
Dominican Republic
Puerto Rico
Peru urban
Peru rural
Venezuela
Mexico urban
Mexico rural
China urban
China rural
India urban
Dementiaa
292 (10.4)
235 (11.7)
233 (11.7)
129 (9.34)
36 (6.5)
140 (7.1)
86 (8.6)
85 (8.5)
81 (7.0)
556 (5.6)
75 (7.5)
Mild cognitive impairment
b
42 (1.5)
26 (1.3)
68 (3.4)
36 (2.6)
18 (3.3)
22 (1.1)
27 (2.7)
32 (3.2)
5 (0.4)
12 (1.2)
33 (3.3)
Stroke
c
216 (7.7)
175 (8.7)
168 (8.4)
112 (8.2)
20 (3.6)
135 (7.0)
67 (6.7)
74 (7.4)
109 (9.4)
18 (1.8)
20 (2.0)
Hypertension
d
1624 (57.9)
968 (48.6)
518 (32.1)
209 (15.2)
37 (6.7)
714 (46.5)
423 (42.2)
371 (37.2)
489 (42.4)
557 (55.6)
608 (60.7)
Alcohol problems
Early life
212 (7.6)
605 (30.4)
132 (6.6)
18 (1.3)
17 (3.1)
88 (7.4)
80 (8.1)
112 (11.3)
26 (2.2)
73 (7.3)
4 (0.4)
Current
103 (3.7)
234 (11.7)
28 (1.4)
3 (0.2)
5 (0.9)
17 (1.5)
9 (0.9)
11 (1.1)
17 (1.5)
42 (4.2)
1 (0.1)
Needs for Care
f
157 (6.4)
143 (7.1)
182 (9.1)
75 (5.4)
10 (1.8)
98 (5.0)
56 (5.6)
30 (3.0)
119 (10.3)
30 (3.0)
14 (1.4)
Depression
g
142 (5.1)
278 (13.8)
47 (2.3)
87 (6.3)
16 (2.9)
107 (5.5)
47 (4.7)
45 (4.5)
3 (0.3)
7 (0.7)
39 (3.9)
a10/66 education-adjusted dementia diagnosis.
bPetersen criteria amnesic MCI.
cSelf reported stroke.
dMeeting ISH hypertension criteria (≥ 14 mmHg systolic and/or ≥ 90 mmHg diastolic).
eHazardous drinker.
fNeeding much care most of the time.
gICD-10 Depression.
The incidence of 10/66 dementia ranged from 18.2 to 30.4 per 1000 person-years, similar
or higher than the incidence of dementia reported for high-income countries. Incidence
of 10/66 dementia was 1.4–2.7 times higher than that for DSM-IV dementia (15.7 and
9.9 per 1000 person-years, respectively).
46
Mortality hazards ratios for dementia ranged from 1.56 to 5.69 by site.
46
Education [hazard ratio (HR): 0.89, 95% confidence interval (CI): 0.81–0.97], and
male sex (0.72, 0.61–0.84) were inversely associated, and older age [risk ratio (RR)
per 5-year band 1.67, 1.56–1.79] were all associated with incident dementia. Literacy,
motor sequencing and verbal fluency all protected against dementia onset, independent
of education, providing support for the cognitive reserve hypothesis.
Crude mortality rates varied from 27.3 to 70.0/1000 person-years, a 3-fold variation
persisting after standardization for demographic and economic factors.
47
A full list of findings and publications can be found on the study website [http://www.alz.co.uk/1066/1066_publications.php]
and in Supplementary Table 4 (available as Supplementary data at IJE online).
What are the main strengths and weaknesses?
One of the main strengths of this study was the use of a one-phase design to estimate
the prevalence, incidence, determinants and consequences of a comprehensive range
of chronic conditions, with a particularly robust dementia assessment procedure specifically
developed and validated for use in LMIC. The same standardized protocol, which included
validated measurements and diagnostic algorithms, was used in each site, permitting
comparison of estimates across diverse settings and aiding the interpretation of observed
variations. The relatively large sample size also allows quite precise estimations
of effect sizes, in particular with meta-analysed pooled estimates. Response rates
were also high, and the number of missing values relatively low. Although the use
of catchment areas increased the response rates, this could have affected the generalizability
of the findings beyond the specific study sites.
Can I get hold of the data? Where can I find out more?
The 10/66 cohort is an open-access database, and we would encourage external investigators
to consider applying to use the data for secondary analyses, in order to maximize
the scientific output from the data. All the information on how to access the 10/66
public data archive, with a list of current proposals and papers currently under preparation,
can be found on our website: [www.alz.co.uk/1066/].
Supplementary Data
Supplementary data are available at IJE online.
Funding
This work was supported by the Wellcome Trust (GR066133/ GR080002), the European Research
Council (340755), US Alzheimer’s Association, WHO, FONDACIT (Venezuela) and the Puerto
Rico State Government, and the Medical Research Council (MR/K021907/1 to A.M.P.)
Conflict of interest: None.
Supplementary Material
Supplementary Data
Click here for additional data file.