As CLINICS completes its 6th year of existence we believe we have reasons for a little
bit of celebration. In June 2010 The Journal of Citation Reports of the Institute
for Scientific Information posted its first Impact Factor for CLINICS, which confirmed
the positive trend we had been monitoring through the Scimago Index of Scopus. Over
the years 2006 – 2008 we had consistently maintained a cites per document level ranging
between 1.0 and 1.3. In June, the 2009 Impact Factor came out at 1.591, the second
highest Brazilian IF.
We also decided to give the journal a face lift and as from August 2010 we are posting
an e‐book of each issue in our internet site. In the near future we hope to make the
entire collection available in this format.
Figure 1 shows monthly article submission for the 2 year period 2009‐2010, showing
the dramatic effect of the posting of the impact factor on submissions, which quadrupled
from May to September. This has meant that the number of published articles also increased
from 12 original research articles in 2009 to 18 in the last months of 2010.
In this final issue of 2010 we publish fifteen original articles of clinical investigation
plus seven of basic research.
Souza et al. evaluated the performance of support vector machine, multi‐layer perceptron
and radial basis function neural networks, as auxiliary tools to identify keratoconus
from Orbscan II maps. They conclude that support vector machine, multi‐layer percetron
classifiers and radial basis function neural network classifiers, trained on Orbscan
II data, could represent useful techniques for keratoconus detection.
Parra et al. performed a a detailed histopathological analysis of the open lung biopsy
of a series of five cases of ARDS confirmed H1N1. They conclude that viral‐like particles
can be successfully demonstrated in lung tissue by ultrastructural examination, particularly
in those patients without RT‐PCR from nasopharingeal aspirate confirmation of the
virus. They also found that bronchioles and epithelium, rather than endothelium, are
probably the primary target of infection and diffuse alveolar damage the consequence
of airways obliteration and dysfunction on innate immunity
Wiedemann et al. correlated preoperative serum N‐terminal pro brain type natriuretic
peptide with the postoperative outcome and mid term survival rates of coronary artery
bypass patients and conclude that these preoperative of levels the peptide >502 ng/ml
predict mid‐term mortality after isolated coronary artry bypass graft and are associated
with significantly higher hospital mortality and perioperative complications.
Franceschini et al. assessed the reliability of the Brazilian version of the Functional
Assessment of Cancer Therapy‐Lung combined with the FACT‐Lung Symptom Index questionnaires
for the measurement of quality of life in patients with lung cancer and conclude that
the Brazilian version is reliable, quick and simple to apply, so that this instrument
can now be used to properly evaluate the quality of life of Brazilian lung cancer
patients.
Jones et al. evaluated the difference in isokinetic strength of hip muscles between
patients with knee osteoarthritis vs. matched healthy controls and conclude that patients
with osteoarthritis of the knee exhibit lower isokinetic strength in the hip muscles
compared with control subjects without osteoarthritis. Strengthening the muscles surrounding
the hip joint would appear to have potential to help decrease pain in people with
knee osteoarthritis.
Kayıran et al. describe 35 patients with Kawasaki disease in Istambul in the most
comprehensive series of children with the disease reported from Turkey. They conclude
that adult onset ischemic heart disease may be due to Kawasaki disease in childhood,
indicating that further prospective clinical investigations are needed to understand
the epidemiology and longterm follow‐up of the disease.
Gualco et al. described the clinical pathological characteristics of 1301 cases of
pediatric/adolescent lymphomas in patients from different geographic regions of Brazil
in what appears to be largest series of pediatric lymphomas presented from Brazil
and suggest that some of the results found in this study may reflect heterogeneous
socio‐economical status and environmental factors of the Brazilian population in the
different regions.
Kikuchi et al. performed a national survey to update hepatocellular carcinoma epidemiology
in Brazil and determined clinical and epidemiological profiles of patients with disease
in different Brazilian regions. including data from 29 centers on 1,405 patients diagnosed
with hepatocellular carcinoma from 2004 to 2009. They found that the epidemiology,
classification, and therapy selection for hepatocellular carcinoma varied among Brazilian
regions. Hepatitis C infection was the most common etiology of liver cirrhosis; chemoembolization
was the most common therapy employed. Liver cirrhosis was the main risk factor for
hepatocellular carcinoma development in Brazil.
Carvalho et al. investigated the clinical and pathological significance of podoplanin
expression in the intratumoral stroma and neoplastic cells of early stage uterine
cervical cancer. A total of 143 patients with clinical stage I and IIA uterine cervical
carcinomas underwent surgery between 2000 and 2007 were surveyed. and conclude that
these preliminary results suggest that podoplanin may have a role in host‐tumor interactions,
and as a result, may represent a favorable prognostic factor for squamous cervical
carcinomas
Medeiros et al. determined the occurrence of depression in 25 women who underwent
conservative surgery for breast cancer with (n = 25) or without (n = 25) breast
reconstruction and compared them to 25 women without breast cancer. The Beck Depression
Inventory was used to measure depression and led to the conclusion that conservative
surgery for breast cancer did not affect the occurrence of depression in women, regardless
of whether breast reconstruction was performed.
Lopes de Melo et al. evaluate the ability of the forced oscillation technique to detect
smoking‐induced respiratory alterations, with special emphasis in early alterations;
and compared the diagnostic accuracy of forced oscillation technique to spirometric
parameters. They conclude that the technique was able to detect the early smoking‐induced
respiratory involvement when pathologic changes are still potentially reversible.
These findings support the use of the forced oscillation technique as a versatile
clinic diagnostic tool helping chronic obstructive pulmonary disease prevention, diagnosis
and treatment.
Bocalini et al. evaluated the effects of short‐term exercise training followed by
six weeks of detraining on the functional fitness of older women after a twelve‐week
water‐based exercise program and conclude that the twelve‐week water‐based exercise
program improves the functional fitness parameters as well as quality of life in older
women. However, they also found that after a short detraining period of 4 to 6 weeks,
the neuromuscular parameters and the quality of life score returned to baseline or
to the untrained subject levels.
Morales et al. investigated morphological and hemodynamic patterns of carotid stenoses
treated by endarterectomy with patch closure versus stenting through a duplex ultrasound
study and claim that both stenting and patch closure were associated with carotid
patency and flow restoration. but alert to the fact that the study does not support
a general approach to new velocity criteria indiscriminately applied to stented or
patched carotids.
Savas et al. investigated the acute effect of phosphodiesterase type 5 inhibitor on
erectile dysfunction via evaluating serum oxidative status and prolidase activity
of sera of 36 patients with erectile dysfunction and 30 control cases and conclude
that the beneficial acute effects of PD5 inhibitor in patients with erectile dysfunction
via evaluating serum oxidative status and prolidase activity.
Ramos et al. evaluated the prevalence of ear creases among patients with peripheral
arterial disease of the lower limbs, compared to patients without documented atherosclerotic
disease and conclude that a higher prevalence of ear creases is independently associated
with peripheral arterial disease and may disclose an external marker for risk identification
The seven original articles on themes of Basic Research are as follows.
Achaval et al. investigated the beneficial effects of treadmill training on hindlimb
motor function and nerve morphometric parameters in diabetic rats submitted to sciatic
nerve crush and conclude that treadmill training is able to accelerate hindlimb motor
function recovery in diabetic injured rats and prevent/revert morphometric alterations
in proximal nerve portions in non‐diabetic and diabetic injured rats.
Valenti et al. evaluated the effects of central catalase inhibition on cardiopulmonary
reflex in conscious Wistar rats and conclude that ATZ (3‐amino‐1,2,4‐triazole) injected
into the fourth cerebral ventricle increases sympathetic inhibition but does not change
the parasympathetic component of the cardiopulmonary reflex in conscious Wistar rats.
Piratelo et al. evaluated the participation of the Angiotensin I, II and 1‐7 on the
left ventricular hypertrophy of Wistar and Spontaneously Hypertensive rats submitted
to sinoaortic denervation. They conclude that not only blood pressure variability
and reduced baroreflex sensitivity but also elevated levels of Angiotensin II and
reduction of the concentration of Angiotensin 1‐7 can contribute to the development
of left ventricular hypertrophy. They clain that the data indicate that baroreflex
dysfunction associated with changes of Renin Angiotensin System may be a predictive
factor of left ventricular hypertrophy and cardiac failure.
Ramos et al. compared the Prophylactic and Therapeutic Use of Short‐Chain Fatty Acid
Enemas in Diversion Colitis in a murine expeimental model. Tey conclude that the therapeutic
use of short‐chain fatty‐acids significantly reduced eosinophilic polymorphonuclear
cells numbers in the intestinal wall and in the colonic lumen; it also reversed the
atrophy of the colonic mucosa; however prophylactic use did not impede the development
of mucosal atrophy.
Kandis et al. studied the effects of Urtica Dioica on Hepatic Ischemia‐Reperfusion
Injury in Rats and found that liver tissue damage was significantly decreased in treated
vs. untreated animals and consequently that it had protective effect on the liver
in hepatic ischemia‐reperfusion injured rats.
Manhães de Castro et al. investigated the effect of fetal under nutrition on the passive
mechanical properties of skeletal muscle of weaned and young adult rats and found
that the increase in passive stiffness in skeletal muscle of weaned rat submitted
to intrauterine under nutrition it is most likely due to changes in muscle passive
stiffness.
Mohd Yusof et al. determine the antiproliferative and apoptosis effects of hot water
extract of Chlorella vulgaris on the hepatoma cell line, HepG2 and conclude that it
may have anticancer effects possibly by inducing apoptosis signaling cascades via
increased expression of P53, Bax and caspase‐3 proteins and reduction of Bcl‐2 protein
which subsequently lead to increased DNA damage and apoptosis.
We also publish a review on publications dealing the the locomotor system in Brzilian
scientific literature, two brief communications and 3 case reports.