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      Association between insulin resistance and hypothyroidism in females attending a tertiary care hospital.

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          Abstract

          The effect of thyroid status on insulin sensitivity is of great interest but despite various studies there is conflicting data on this subject. The study group comprised of 25 female subjects each with subclinical hypothyroidism, overt hypothyroidism and euthyroid controls. Serum samples of all the patients were assayed for thyroid profile, Insulin and lipid profile. Homeostasis model of assessment (HOMA-IR) was employed to assess the level of insulin resistance. Patients with hypothyroidism demonstrated insulin resistance and dyslipidemia as observed by the higher HOMA-IR and cholesterol and triglyceride levels respectively as compared to the controls. A significantly positive correlation between TSH and HOMA-IR level was also observed in the hypothyroidism group. Thyroid dysfunction leads to alterations in glucose and lipid metabolism which is an important risk factor for cardiovascular diseases. The dyslipidemia and insulin resistance should be managed aggressively to reduce the impending risk.

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          Author and article information

          Journal
          Indian J Clin Biochem
          Indian journal of clinical biochemistry : IJCB
          Springer Nature America, Inc
          0970-1915
          0970-1915
          Apr 2010
          : 25
          : 2
          Affiliations
          [1 ] Department of Biochemistry, G B Pant Hospital, New Delhi, India ; Department of Biochemistry, G B Pant Hospital, Room No 418, New Delhi, 110002 India.
          Article
          26
          10.1007/s12291-010-0026-x
          3453097
          23105900

          TSH, Dyslipidemia, HOMA-IR, Hypothyroidism, Insulin

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