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      Physical Activity, Sedentary Behavior, and Inflammatory and Hemostatic Markers in Men

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          Abstract

          This study aimed to determine whether higher levels of physical activity (PA) and less sedentary behavior (SB) are associated with less inflammation, indicated by inflammatory and hemostatic biomarkers, in older men.

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          The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease.

          Michael Gleeson, Nicolette C Bishop, David J Stensel … (2011)
          Regular exercise reduces the risk of chronic metabolic and cardiorespiratory diseases, in part because exercise exerts anti-inflammatory effects. However, these effects are also likely to be responsible for the suppressed immunity that makes elite athletes more susceptible to infections. The anti-inflammatory effects of regular exercise may be mediated via both a reduction in visceral fat mass (with a subsequent decreased release of adipokines) and the induction of an anti-inflammatory environment with each bout of exercise. In this Review, we focus on the known mechanisms by which exercise - both acute and chronic - exerts its anti-inflammatory effects, and we discuss the implications of these effects for the prevention and treatment of disease.
          Article 0 comments Cited 397 times – based on 0 reviews     Review now
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            The origins of age-related proinflammatory state.

            Fulvio Lauretani, Benedetta Bartali, Luigi Ferrucci … (2005)
            We hypothesized that the rising levels of inflammatory markers with aging is explained by cardiovascular risk factors and morbidity becoming progressively more prevalent in older persons. Information on inflammatory markers, cardiovascular risk factors, and diseases was collected in 595 men and 748 women sampled from the general population (age, 20-102 years). In both men and women, older age was associated with higher levels of interleukin-6 (IL-6), IL-1 receptor antagonist (IL-1ra), IL-18, C-reactive protein (CRP), and fibrinogen, while soluble IL-6 receptor (sIL-6r) increased significantly with age only in men. Adjusting for cardiovascular risk factors and morbidity, the age regression coefficients became substantially smaller in models predicting IL-6, IL-1ra, IL-18, and fibrinogen and larger in the model predicting sIL6r. Adjustment for cardiovascular morbidity substantially reduced the effect of age on CRP in men but not in women. Findings were confirmed in a subgroup of 51 men and 45 women with low risk profile and no cardiovascular morbidity. Part of the "proinflammatory state" in older persons is related to the high prevalence of cardiovascular risk factor and morbidity.
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              How Sedentary are Older People? A Systematic Review of the Amount of Sedentary Behavior.

              Juliet Harvey, Sebastien Chastin, Dawn Skelton (2015)
              Sedentary behavior (SB), defined as sitting (nonexercising), reclining, and lying down (posture), or by low energy expenditure, is a public health risk independent to physical activity. The objective of this systematic literature review was to synthesize the available evidence on amount of SB reported by and measured in older adults.
              Article 0 comments Cited 104 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: Medicine & Science in Sports & Exercise
                Publisher: Ovid Technologies (Wolters Kluwer Health)
                ISSN (Print): 0195-9131
                Publication date Created: 2017
                Publication date (Print): March 2017
                Volume: 49
                Issue: 3
                Pages: 459-465
                Article
                DOI: 10.1249/MSS.0000000000001113
                PMC ID: 5330416
                PubMed ID: 28222056
                SO-VID: f6580bd9-ae1f-4ec2-b9fc-3c759689082b
                Copyright © © 2017
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