Plasma Levels of Aldosterone Precursors (Including the 18-Hydroxylated Compounds in this Synthesis Pathway) – A Tool for the Analysis of Adrenal Disorders?

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Abstract

Some current ideas concerning the 18-hydroxylated corticosteroids (18-hydroxycorticosterone and 18-hydroxydeoxycorticosterone) and the other steroids of the mineralocorticosteroid pathway from deoxycorticosterone (DOC) are reviewed. Then, some recent findings from our own laboratory, obtained during the analysis of all aldosterone precursors from DOC in various adrenal disorders, such as enzyme deficiencies, and particularly adrenal masses detected in patients from various hospitals in France are discussed. The findings reported here show that these specialized assays can be valuable tools to determine adrenal function in complex cases.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISBN: 978-3-8055-5316-2

ISBN: 978-3-318-01936-0

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1990

Publication date (Print): 1990

Publication date (Electronic): 02 December 2008

Volume: 34

Issue: 3-4

Pages: 142-150

Affiliations

Service de Biochimie (Dir. Prof. Legrand), CHU Pitié-Salpêtrière, Paris, France

Article

Publisher ID: 181814 Other ID: Horm Res 1990;34:142–150

DOI: 10.1159/000181814

PubMed ID: 1966563

SO-VID: f6586f98-d942-4893-a1b1-23ba96adf4ad

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Plasma Levels of Aldosterone Precursors (Including the 18-Hydroxylated Compounds in this Synthesis Pathway) – A Tool for the Analysis of Adrenal Disorders?

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Karger: Endocrinology

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