Cosmetic preservatives as therapeutic corneal and scleral tissue cross-linking agents.

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Abstract

Previously, aliphatic β-nitroalcohols (BNAs) have been studied as a means to chemically induce tissue cross-linking (TXL) of cornea and sclera. There are a number of related and possibly more potent agents, known as formaldehyde releasers (FARs), that are in commercial use as preservatives in cosmetics and other personal care products. The present study was undertaken in order to screen such compounds for potential clinical utility as therapeutic TXL agents.

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Journal

Journal ID (iso-abbrev): Invest. Ophthalmol. Vis. Sci.

Title: Investigative ophthalmology & visual science

Publisher: Association for Research in Vision and Ophthalmology (ARVO)

ISSN (Electronic): 1552-5783

ISSN (Print): 0146-0404

Publication date (Electronic): Jan 29 2015

Volume: 56

Issue: 2

Affiliations

[1 ] Department of Ophthalmology, Columbia University College of Physicians and Surgeons, New York, New York, United States.

Article

Publisher Item ID: iovs.14-16035

DOI: 10.1167/iovs.14-16035

PMC ID: 4338628

PubMed ID: 25634979

SO-VID: f66306e2-66c3-4fd4-8bc1-17131242c9cd

History

Keywords: keratoconus,progressive myopia,sclera,tissue cross-linking,cornea

Data availability:

Keywords: keratoconus, progressive myopia, sclera, tissue cross-linking, cornea

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