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      The 2016 HIV diagnosis and care cascade in New South Wales, Australia: meeting the UNAIDS 90‐90‐90 targets

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          Abstract

          Introduction

          The HIV Strategy in New South Wales ( NSW) Australia aims to virtually eliminate HIV transmission by 2020. We estimated the 2016 HIV diagnosis and care cascade for the state of NSW, with a focus on introducing population‐based data to improve data quality and assess progress towards the UNAIDS 90‐90‐90 targets.

          Methods

          To estimate the number of people living with diagnosed HIV ( PLDHIV) we used NSW data from the Australian National HIV Registry, enhanced by surveillance among people recently diagnosed with HIV to improve migration estimates. The number of undiagnosed PLHIV was estimated using back‐projection modelling by CD4 count at diagnosis. De‐duplicated prescription claims data were obtained from the Australian Pharmaceutical Benefits Scheme ( PBS), and were combined with an estimate for those ineligible, to determine the number of PLDHIV on antiretroviral therapy ( ART). Data from a clinic network with 87% coverage of PLDHIV in NSW enabled the estimation of the number on ART who had HIV suppression.

          Results and discussion

          We estimated that 10,110 PLHIV resided in NSW in 2016 (range 8400 to 11,720), among whom 9230 (91.3%) were diagnosed, and 8490 (92.0% of those diagnosed) were receiving ART. Among PLDHIV receiving ART, 8020 (94.5%) had suppressed viral load (<200 HIV‐1 RNA copies/ mL). Overall, 79.3% of all PLHIV had HIV virological suppression.

          Conclusion

          NSW has met each of the UNAIDS 90‐90‐90 targets. The enhanced surveillance methods and data collection systems improved data quality. Measuring and meeting the 90‐90‐90 targets is feasible and could be achieved in comparable parts of the world.

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          Most cited references10

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          Association of Implementation of a Universal Testing and Treatment Intervention With HIV Diagnosis, Receipt of Antiretroviral Therapy, and Viral Suppression in East Africa

          Question Was implementation of a human immunodeficiency virus (HIV) test-and-treat intervention in rural East Africa associated with increases in diagnosis, treatment, and viral suppression among individuals with HIV infection? Findings In this study that included 77 774 residents of the intervention communities of an ongoing cluster randomized trial, the proportion of HIV-positive individuals with HIV viral suppression increased from 44.7% at baseline to 80.2% after 2 years, along with increases in HIV diagnosis and initiation of antiretroviral therapy. Meaning Implementation of a community-based testing and treatment intervention in East Africa was associated with increased proportion of HIV-positive individuals who achieved viral suppression, along with increased HIV diagnosis and initiation of antiretroviral therapy. Importance Antiretroviral treatment (ART) is now recommended for all HIV-positive persons. UNAIDS has set global targets to diagnose 90% of HIV-positive individuals, treat 90% of diagnosed individuals with ART, and suppress viral replication among 90% of treated individuals, for a population-level target of 73% of all HIV-positive persons with HIV viral suppression. Objective To describe changes in the proportions of HIV-positive individuals with HIV viral suppression, HIV-positive individuals who had received a diagnosis, diagnosed individuals treated with ART, and treated individuals with HIV viral suppression, following implementation of a community-based testing and treatment program in rural East Africa. Design, Setting, and Participants Observational analysis based on interim data from 16 rural Kenyan (n = 6) and Ugandan (n = 10) intervention communities in the SEARCH Study, an ongoing cluster randomized trial. Community residents who were 15 years or older (N = 77 774) were followed up for 2 years (2013-2014 to 2015-2016). HIV serostatus and plasma HIV RNA level were measured annually at multidisease health campaigns followed by home-based testing for nonattendees. All HIV-positive individuals were offered ART using a streamlined delivery model designed to reduce structural barriers, improve patient-clinician relationships, and enhance patient knowledge and attitudes about HIV. Main Outcomes and Measures Primary outcome was viral suppression (plasma HIV RNA<500 copies/mL) among all HIV-positive individuals, assessed at baseline and after 1 and 2 years. Secondary outcomes included HIV diagnosis, ART among previously diagnosed individuals, and viral suppression among those who had initiated ART. Results Among 77 774 residents (male, 45.3%; age 15-24 years, 35.1%), baseline HIV prevalence was 10.3% (7108 of 69 283 residents). The proportion of HIV-positive individuals with HIV viral suppression at baseline was 44.7% (95% CI, 43.5%-45.9%; 3464 of 7745 residents) and after 2 years of intervention was 80.2% (95% CI, 79.1%-81.2%; 5666 of 7068 residents), an increase of 35.5 percentage points (95% CI, 34.4-36.6). After 2 years, 95.9% of HIV-positive individuals had been previously diagnosed (95% CI, 95.3%-96.5%; 6780 of 7068 residents); 93.4% of those previously diagnosed had received ART (95% CI, 92.8%-94.0%; 6334 of 6780 residents); and 89.5% of those treated had achieved HIV viral suppression (95% CI, 88.6%-90.3%; 5666 of 6334 residents). Conclusions and Relevance Among individuals with HIV in rural Kenya and Uganda, implementation of community-based testing and treatment was associated with an increased proportion of HIV-positive adults who achieved viral suppression, along with increased HIV diagnosis and initiation of antiretroviral therapy. In these communities, the UNAIDS population-level viral suppression target was exceeded within 2 years after program implementation. Trial Registration clinicaltrials.gov Identifier: NCT01864683 This analysis examines intervention communities in rural Uganda and Kenya in an ongoing cluster randomized trial to assess the change in the proportions of HIV-positive residents diagnosed with HIV, treated with ART, and achieving HIV viral suppression.
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            Migration distorts surveillance estimates of engagement in care: results of public health investigations of persons who appear to be out of HIV care.

            Prevention and clinical efforts are increasingly focused on improving the HIV care cascade, the sequential steps from diagnosis to engagement in care and viral suppression. Monitoring of this cascade is largely dependent on HIV laboratory surveillance data. However, little is known about the completeness of these data or the true care status of individuals for whom no data are reported.
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              Use of multiple data sources and individual case investigation to refine surveillance-based estimates of the HIV care continuum.

              To assess the HIV care continuum among HIV-infected persons residing in Seattle and King County, WA, at the end of 2011 and compare estimates of viral suppression derived from different population-based data sources.
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                Author and article information

                Contributors
                pkeen@kirby.unsw.edu.au
                Journal
                J Int AIDS Soc
                J Int AIDS Soc
                10.1002/(ISSN)1758-2652
                JIA2
                Journal of the International AIDS Society
                John Wiley and Sons Inc. (Hoboken )
                1758-2652
                20 April 2018
                April 2018
                : 21
                : 4 ( doiID: 10.1002/jia2.2018.21.issue-4 )
                : e25109
                Affiliations
                [ 1 ] The Kirby Institute UNSW Sydney Sydney Australia
                [ 2 ] Health Protection NSW Sydney Australia
                [ 3 ] NSW Ministry of Health Sydney Australia
                [ 4 ] Centre for Social Research in Health UNSW Sydney Sydney Australia
                [ 5 ] The Burnet Institute Melbourne Australia
                Author notes
                [*] [* ] Corresponding author: Phillip Keen, The Kirby Institute, UNSW Sydney, Sydney NSW 2052, Australia. ( pkeen@ 123456kirby.unsw.edu.au )
                [†]

                A complete list of the NSW HIV Prevention Partnership Project investigators is given in the Appendix.

                Author information
                http://orcid.org/0000-0002-2678-0645
                http://orcid.org/0000-0002-2885-0483
                http://orcid.org/0000-0002-2586-8274
                Article
                JIA225109
                10.1002/jia2.25109
                5909111
                29676000
                f66ec78d-378e-485a-878e-528229e94f5f
                © 2018 The Authors. Journal of the International AIDS Society published by John Wiley & sons Ltd on behalf of the International AIDS Society.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 06 November 2017
                : 27 March 2018
                Page count
                Figures: 1, Tables: 1, Pages: 6, Words: 4856
                Funding
                Funded by: Australian Government Department of Health and Ageing
                Funded by: NHMRC Partnership Grant
                Award ID: 1092852
                Funded by: NSW Ministry of Health
                Funded by: UNSW Sydney
                Funded by: Australian Department of Health and Ageing
                Categories
                Short Report
                Short Reports
                Custom metadata
                2.0
                jia225109
                April 2018
                Converter:WILEY_ML3GV2_TO_NLMPMC version:version=5.3.4 mode:remove_FC converted:20.04.2018

                Infectious disease & Microbiology
                90‐90‐90,antiretroviral treatment,continuum of care,hiv,treatment cascade

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