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Histone deacetylase 8 in neuroblastoma tumorigenesis.
Ina Oehme
1 ,
Hedwig E Deubzer ,
Dennis Wegener ,
Diana Pickert ,
Jan-Peter Linke ,
Barbara Hero ,
Annette Kopp-Schneider ,
Frank Westermann ,
Scott M Ulrich ,
Andreas von Deimling ,
Matthias Fischer ,
Olaf Witt
Jan 01 2009
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Abstract
The effects of pan-histone deacetylase (HDAC) inhibitors on cancer cells have shown that HDACs are involved in fundamental tumor biological processes such as cell cycle control, differentiation, and apoptosis. However, because of the unselective nature of these compounds, little is known about the contribution of individual HDAC family members to tumorigenesis and progression. The purpose of this study was to evaluate the role of individual HDACs in neuroblastoma tumorigenesis.