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      Improvement of seminal quality and sexual function of men with oligoasthenoteratozoospermia syndrome following supplementation with L-arginine and Pycnogenol®

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          Abstract

          We evaluated the effectiveness of antioxidant co-supplementation therapy using Larginine and Pycnogenol<sup>®</sup> in Japanese men with oligoasthenozoospermia and mild erectile dysfunction (ED). A total of forty-seven adult males with oligoasthenoteratozoospermia syndrome (OAT) were eligible for enrollment. The effectiveness of supplementation with a combination of L-arginine 690 mg and French maritime pine bark extract (Pycnogenol<sup>®</sup>) 60mg for OAT and ED was investigated. The sperm concentration was enhanced significantly after treatment 2 and 4 months (11.79 ± 9.86 to 21.22 ± 28.17 and 20.15 ± 23.99 × 106/ml). Significant improvements in the International Index of Erectile Function (IIEF) were observed in the total score of IIEF (57.69 ± 11.04 to 59.43 ± 12.57) and domain of Orgasmic Function (9.01 ± 1.92 to 9.34 ± 1.66) after 4 months of treatment. L-arginine acts to increase the production of nitric oxide and Pycnogenol<sup>®</sup> activates the endothelial nitric oxide synthase and it is a potent antioxidant and inhibitor of inducible nitric oxide synthase. This study suggests that the combination of Pycnogenol<sup>®</sup> and L-arginine (Edicare<sup>®</sup>) is helpful for infertile men to ameliorate simultaneously quality of sperms as well as erectile functions.

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          Author and article information

          Journal
          Archivio Italiano di Urologia e Andrologia
          Arch Ital Urol Androl
          PAGEPress Publications
          2282-4197
          1124-3562
          September 30 2015
          September 30 2015
          : 87
          : 3
          : 190
          Article
          10.4081/aiua.2015.3.190
          26428638
          f6867c98-9961-47b9-96a1-f68686a962a8
          © 2015
          History

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