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      Treatment of severe psoriasis with infliximab

      ,

      Therapeutics and Clinical Risk Management

      Dove Medical Press

      psoriasis, pathogenesis, co-morbidities, treatment, infliximab

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          Abstract

          Psoriasis is a chronic, immune mediated inflammatory disease characterized by increased cell signalling via cytokines and chemokines on a background of up-regulated gene expression. There is substantial evidence that psoriasis should be regarded as more than a cutaneous disease; major psychological morbidity and increased mortality from cardiovascular disease and cancer are increasingly recognized. Improved understanding of the genetic and immunological mechanisms underpinning psoriasis has occurred concurrently with the development of targeted biological therapies including infliximab. These newer therapeutic approaches can be very effective but their long term safety profile is not yet fully determined.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          December 2008
          December 2008
          : 4
          : 6
          : 1165-1176
          Affiliations
          Alan Lyell Centre for Dermatology, Western Infirmary, Glasgow, UK
          Author notes
          Correspondence: Joyce Leman, Alan Lyell Centre for Dermatology, Western Infirmary, Glasgow, G11 6NT, UK, Tel +44 141 211 2540, Email joyceleman@ 123456nhs.net
          Article
          tcrm-4-1165
          2643098
          19337424
          © 2008 Dove Medical Press Limited. All rights reserved
          Categories
          Review

          Medicine

          co-morbidities, pathogenesis, treatment, psoriasis, infliximab

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