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      Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice.

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          Abstract

          Cerebral ischemia and reperfusion is associated with activation of the coagulation cascade and fibrin deposition in cerebral microvessels. Both thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen activator inhibitor-1 (PAI-1) attenuate fibrinolysis and are therefore attractive targets for the treatment of ischemic stroke.

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          Author and article information

          Journal
          Stroke
          Stroke
          Ovid Technologies (Wolters Kluwer Health)
          1524-4628
          0039-2499
          Sep 2016
          : 47
          : 9
          Affiliations
          [1 ] From the Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, Belgium (F.D., N.V., H.D., K.V., S.F.D.M.); and Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium (T.W., M.P., A.G., P.J.D.).
          [2 ] From the Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, Belgium (F.D., N.V., H.D., K.V., S.F.D.M.); and Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium (T.W., M.P., A.G., P.J.D.). simon.demeyer@kuleuven.be.
          Article
          STROKEAHA.116.014091
          10.1161/STROKEAHA.116.014091
          27470988
          f6b3a50a-af41-4fb8-94f2-510503a054cc
          History

          fibrinolysis,plasminogen activator inhibitor-1,reperfusion injury,stroke,thrombin-activatable fibirinolysis inhibitor

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