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      • Record: found
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      A Model of Long-Term Peritoneal Dialysis in the Dog

      , , ,

      Nephron

      S. Karger AG

      Dog, Anephric dog, Hydronephrotic dog, Peritoneal dialysis

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          Abstract

          We describe two preparations for chronic peritoneal dialysis in the dog. In one group uremia was induced by nephrectomy and in the other by ureteral ligation. Peritoneal access was obtained using the Ash disc column catheter. Survival of the animals ranged from 27 to 83 days. Using a dialysis schedule similar in concept to continuous ambulatory peritoneal dialysis in man we found that dialysate-induced ultrafiltration, equilibration of solute between serum and dialysate, as well as protein losses into dialysate approximated values found in patients undergoing continuous ambulatory peritoneal dialysis. Careful attention to detail is required in order to maintain these animals. The advantages of these models are their technical simplicity and prolonged survival making intermediate range studies feasible. Disadvantages include anemia, seen in the anephric animals, technical problems with the disc column catheter, the need for maintenance of strict aseptic technique when performing dialysis exchanges, and difficulties maintaining adequate nutrition.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1983
          1983
          03 December 2008
          : 35
          : 4
          : 259-263
          Affiliations
          Department of Medicine, University of Mississippi Medical Center, Jackson, Miss., USA
          Article
          183093 Nephron 1983;35:259–263
          10.1159/000183093
          6646300
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Hydronephrotic dog, Anephric dog, Peritoneal dialysis, Dog

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