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      Pathology of Corneal Endothelium in Keratoconus

      S. Karger AG
      Keratoconus, Human corneal endothelium, Histopathology

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          Keratoconus is characterized by stromal thinning and conical deformity of the cornea that affects a small but significant portion of the population. Although keratoconus has been well studied, endothehal changes have not been extensively investigated. We studied the endothelium of 14 keratoconus corneal buttons obtained over the past 6 years by penetrating keratoplasty using light microscopy, scanning electron microscopy and transmission electron microscopy. Observations were correlated with patient history. Corneas demonstrated: endothehal cell pleomorphism and polymegathism (6 corneas); endothehal cell degeneration (13), and evidence of anterior chamber inflammation (4). Patterns of endothehal damage were variable ranging from isolated cell membranolysis to denudement of Descemet’s membrane. Less damage was present at the apex of the cones than that observed in a circumferential pattern at the bases. In general the damage observed correlated with the severity and duration of the keratoconus with 9 years being the dividing time between mild and severe endothehal cell damage. These observations support other studies that implicate contact lens wear as a cause of pleomorphism and polymegathism in these patients. Endothehal cell alterations are likely a secondary event occurring due to mechanical stresses.

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          Author and article information

          S. Karger AG
          01 April 2010
          : 206
          : 4
          : 192-208
          Departments of Ophthalmology and Pathology, School of Medicine, University of North Carolina at Chapel Hill, N.C., USA
          310390 Ophthalmologica 1993;206:192–208
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 23 October 1992
          : 31 October 1992
          Page count
          Pages: 17
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Keratoconus,Human corneal endothelium,Histopathology


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