+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Effect of Various Traumatic Stresses on Growth Hormone Release in Pentobarbital Anesthetized Rats

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Catheterization of the femoral artery using rubber band restraint markedly lowered growth hormone (GH) levels in plasma of male rats which had been anesthetized with pentobarbital (PB). Other stressful factors existing in the process of catheterization, such as skin incision, soft tissue separation to expose the femoral artery, restraint on the back, catheterization with scotch tape restraint and catheterization without restraint, did not produce a significant suppression of plasma GH levels. On the other hand, in all catheterization a marked increase in plasma corticosterone (CS) levels was observed. When the tibia was broken in anesthetized rats, plasma GH levels dropped within 15 min, then gradually increased. However, use of a rubber band tourniquet for a long period caused a marked suppression of GH within 15 min which was maintained for 75 min. If the rubber band was removed 15 min after application, plasma GH levels gradually increased to pre-stress levels in 60 min. A spinal cord section prevented the suppressive effects of the rubber band tourniquet and tibia break on GH release. These results indicate that a strong stress, such as a rubber band tourniquet, inhibits the stimulatory effect of PB on GH release as long as the stress is continued.

          Related collections

          Author and article information

          S. Karger AG
          26 March 2008
          : 26
          : 1
          : 1-7
          Department of Medical Chemistry, Tokyo Metropolitan Institute for Neurosciences, Fuchu-city, Tokyo
          122764 Neuroendocrinology 1978;26:1–7
          © 1978 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7


          Comment on this article