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      Transport of Amino Acids and Related Compounds from Plasma to Aqueous Humour in Man

      , ,

      Ophthalmic Research

      S. Karger AG

      Aqueous humour, Amino acids, Filtration, Secretion, Human, Transport

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          Abstract

          The concentrations of 19 amino acids and related compounds were simultaneously determined in the aqueous humour (C<sub>aq</sub>) and plasma (C<sub>pl</sub>) of 40 patients with various ocular disorders, by means of ion-exchange chromatography. The purpose of the study was to elucidate the transport across the blood-aqueous barrier in man by studying the relationship between C<sub>aq</sub> and C<sub>pl</sub> for each substance. Graphs of C<sub>aq</sub> versus C<sub>pl</sub> revealed for most substances a positive correlation, supported by a statistical regression analysis. It may be concluded by the use of a simple kinetic model that the transport of threonine, glutamine (containing serine and asparagine), α-aminobutyric acid, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, arginine, proline, alanine, lysine and histidine must in part take place by means of secretion, whereas for taurine, urea, glutamic acid, glycine and cystine no such evidence for secretion has been found, but neither has it been excluded.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1976
          1976
          03 December 2009
          : 8
          : 1
          : 64-80
          Affiliations
          Institute of Medical Biochemistry, and Department of Ophthalmology, Århus Kommunehospital, University of Aarhus, Aarhus
          Article
          264800 Ophthalmic Res 1976;8:64–80
          10.1159/000264800
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 17
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