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Landscape Diversity Related to Buruli Ulcer Disease in Côte d'Ivoire

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      Abstract

      Background

      Buruli ulcer disease (BU), due to the bacteria Mycobacterium ulcerans, represents an important and emerging public health problem, especially in many African countries. Few elements are known nowadays about the routes of transmission of this environmental bacterium to the human population.

      Methodology/Principal Findings

      In this study, we have investigated the relationships between the incidence of BU in Côte d'Ivoire, western Africa, and a group of environmental variables. These environmental variables concern vegetation, crops (rice and banana), dams, and lakes. Using a geographical information system and multivariate analyses, we show a link between cases of BU and different environmental factors for the first time on a country-wide scale. As a result, irrigated rice field cultures areas, and, to a lesser extent, banana fields as well as areas in the vicinity of dams used for irrigation and aquaculture purposes, represent high-risk zones for the human population to contract BU in Côte d'Ivoire. This is much more relevant in the central part of the country.

      Conclusions/Significance

      As already suspected by several case-control studies in different African countries, we strengthen in this work the identification of high-risk areas of BU on a national spatial scale. This first study should now be followed by many others in other countries and at a multi-year temporal scale. This goal implies a strong improvement in data collection and sharing in order to achieve to a global picture of the environmental conditions that drive BU emergence and persistence in human populations.

      Author Summary

      Buruli ulcer (BU) is one of the most neglected but treatable tropical diseases. The causative organism, Mycobacterium ulcerans, is from the family of bacteria that causes tuberculosis and leprosy. This severe skin disease leads to long-term functional disability if not treated. BU has been reported in over 30 countries mainly with tropical and subtropical climates, but Côte d'Ivoire is one of the most affected countries. M. ulcerans is an environmental bacterium and its mode of transmission to humans is still unclear, such that the disease is often referred to as the “mysterious disease” or the “new leprosy”. Here, we explored the relationship between environmental and socioeconomic factors and BU cases on a nationwide scale. We found that irrigated rice field cultures areas, and, to a lesser extent, banana fields as well as areas in the vicinity of dams used for irrigation and aquaculture purposes, represent high risk zones for the human population to contract BU in Côte d'Ivoire. This work identifies high-risk areas for BU in Côte d'Ivoire and deserves to be extended to different countries. We need now to obtain a global vision and understanding of the route of transmission of M. ulcerans to humans in order to better implement control strategies.

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      Most cited references 48

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      Categorical Data Analysis

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        Emerging infectious diseases of wildlife--threats to biodiversity and human health.

        Emerging infectious diseases (EIDs) of free-living wild animals can be classified into three major groups on the basis of key epizootiological criteria: (i) EIDs associated with "spill-over" from domestic animals to wildlife populations living in proximity; (ii) EIDs related directly to human intervention, via host or parasite translocations; and (iii) EIDs with no overt human or domestic animal involvement. These phenomena have two major biological implications: first, many wildlife species are reservoirs of pathogens that threaten domestic animal and human health; second, wildlife EIDs pose a substantial threat to the conservation of global biodiversity.
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          The challenge of emerging and re-emerging infectious diseases.

          Infectious diseases have for centuries ranked with wars and famine as major challenges to human progress and survival. They remain among the leading causes of death and disability worldwide. Against a constant background of established infections, epidemics of new and old infectious diseases periodically emerge, greatly magnifying the global burden of infections. Studies of these emerging infections reveal the evolutionary properties of pathogenic microorganisms and the dynamic relationships between microorganisms, their hosts and the environment.
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            Author and article information

            Affiliations
            [1 ]Université d'Artois, Faculté d'Histoire-Géographie, Arras, France
            [2 ]Génétique et Evolution des Maladies Infectieuses, GEMI-UMR 2724 IRD-CNRS, Equipe “Dynamique des Systèmes et Maladies Infectieuses”, Montpellier, France
            [3 ]Institut Raoul Follereau d'Adopzé, Université de Cocody, UFR des Sciences Médicales, Abidjan, Côte d'Ivoire
            University of Tennessee, United States of America
            Author notes
            [¤]

            Current address: Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America

            Conceived and designed the experiments: TB HB JFG. Analyzed the data: TB HB EE JFG. Contributed reagents/materials/analysis tools: HB EE HA. Wrote the paper: TB HB EE HA JFG.

            Contributors
            Role: Editor
            Journal
            PLoS Negl Trop Dis
            plos
            plosntds
            PLoS Neglected Tropical Diseases
            Public Library of Science (San Francisco, USA )
            1935-2727
            1935-2735
            July 2008
            30 July 2008
            : 2
            : 7
            2474700
            18665259
            07-PNTD-RA-0109R3
            10.1371/journal.pntd.0000271
            (Editor)
            Brou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
            Counts
            Pages: 9
            Categories
            Research Article
            Ecology/Spatial and Landscape Ecology
            Infectious Diseases/Epidemiology and Control of Infectious Diseases
            Infectious Diseases/Neglected Tropical Diseases

            Infectious disease & Microbiology

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