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      Diabetes, a new mutation in the mouse.

      Science (New York, N.Y.)

      Animals, Blood Glucose, Body Weight, Diabetes Mellitus, genetics, Female, Male, Mice, Mutation

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          Abstract

          Diabetes (db), which occurred in an inbred strain of mouse, is inherited as a unit autosomal recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in man. Abnormal deposition of fat at 3 to 4 weeks of age is followed shortly by hyperglycemia, polyuria, and glycosuria. Accompanying morphological changes in the islets of Langerhans suggest neogenesis to compensate for insulin depletion.

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          Journal
          5918576

          Chemistry

          Animals, Blood Glucose, Body Weight, Diabetes Mellitus, genetics, Female, Male, Mice, Mutation

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