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      Prevention of bone mineral loss in postmenopausal women by norethisterone.

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      Obstetrics and gynecology

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          Abstract

          The effect of norethisterone on bone mineral metabolism was examined in 43 postmenopausal women. A significant decline in serum calcium, phosphate, and alkaline phosphatase in urinary calcium/creatinine ratio and in tubular maximum reabsorption of phosphate was demonstrated. There was no alteration in urinary hydroxyproline/creatinine ratio. The bone mineral content measured over two years by single photon absorptiometry was compared in 20 patients receiving norethisterone and a matched control group receiving placebo. There was significant protection against bone loss in the norethisterone group.

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          Author and article information

          Journal
          Obstet Gynecol
          Obstetrics and gynecology
          0029-7844
          0029-7844
          Dec 1985
          : 66
          : 6
          4069480

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