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      Simultaneous quantification of oestrogens and androgens in the serum of patients with benign prostatic hyperplasia by liquid chromatography-Tandem mass spectrometry.

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          Abstract

          Benign prostate hyperplasia (BPH) is a common disease in elderly men. It has been found that the occurrence of BPH was closely related to dysregulated steroid hormones. Here, a rapid, sensitive, accurate and specific method for the quantitative profiling of five androgens in man serum was developed and validated by the use of liquid chromatography-tandem mass spectrometry (LC-MS/MS). Using this method, dehydroepiandrosterone (DHEA), androstenedione (A4), testosterone (T), androsterone (A), dihydrotestosterone (DHT), oestrone (E1) and oestradiol (E2) were quantified in serum from man with and without BPH. BPH patients were characterised by the decreases in DHEA, A4 and T as well as increases in DHT, E2 and E1 in serum. Meanwhile, DHEA and DHT in serum were screened as sensitive biomarkers of BPH patients. This study will provide a new perspective of dysregulated steroid hormones for the diagnosis and prevention of BPH.

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          Author and article information

          Journal
          Andrologia
          Andrologia
          Wiley
          1439-0272
          0303-4569
          Aug 2020
          : 52
          : 7
          Affiliations
          [1 ] Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China.
          [2 ] Department of Pharmacy, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
          [3 ] Department of Urology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
          [4 ] Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China.
          Article
          10.1111/and.13611
          32441855
          f70b6ee8-8b2b-4991-a43f-1f8ad4bfbc2a
          © 2020 Blackwell Verlag GmbH.

          LC-MS/MS,androgens,benign prostate hyperplasia,clinical samples,hormones homeostasis,oestrogens

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