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      Role of Sodium and Renal Prostaglandin E 2 in the Maintenance of Hypertension in the Chronic Phase of Two-Kidney One-Clip Renovascular Hypertension in Rabbits

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          Abstract

          To study the role of sodium and renal prostaglandin E<sub>2</sub> in the chronic phase of two-kidney one-clip renovascular hypertension, urinary excretion rates of sodium and prostaglandin E<sub>2</sub> were measured in rabbits with hypertension induced by left renal artery constriction during alteration in sodium intake. The arterial blood pressure, the increasing rate of body weight and sodium balance during alteration in sodiurm intake were directly proportional to the amount of sodium intake in the hypertensive rabbits, but not in the control ones. Plasma renin activity and plasma aldosterone concentration, which had no significant difference between hypertensive and control rabbits, were inversely proportional to the amount of sodium intake in both rabbits. Urinary excretion rates of sodium in the clipped kidneys of the hypertensive rabbits were significantly lower than the control values in all dietary regimens (p < 0.01). Urinary excretion rates of sodium in the nonclipped kidneys were not significantly higher and in the total kidneys were significantly lower than the corresponding control values during sodium load (p < 0.01). Urinary excretion rates of prostaglandin E<sub>2</sub> were inversely proportional to the amount of sodium intake in both groups. Urinary excretion rates of prostaglandin E<sub>2</sub> in the clipped kidneys were significantly lower than the control values in all dietary regimens (p < 0.001). Urinary excretion rates of prostaglandin E<sub>2</sub> in the nonclipped kidneys were significantly higher during sodium restriction (p < 0.01) but not during sodium load than the control values. Furthermore, urinary excretion rates of prostaglandin E<sub>2</sub> in the total kidneys were significantly lower than the control values in all dietary regimens (p < 0.01). These results suggest that two-kidney one-clip renovascular hypertension in rabbits seems to be partly sodium-dependent in the chronic phase because the nonclipped kidney fails to excrete sodium sufficiently. There may also be disorders of renal prostaglandin E<sub>2</sub> metabolism influencing these disorders of sodium in the nonclipped kidneys.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1988
          1988
          09 December 2008
          : 49
          : 1
          : 74-80
          Affiliations
          Department of Urology, Kumamoto University Medical School, Kumamoto, Japan
          Article
          184990 Nephron 1988;49:74–80
          10.1159/000184990
          3164091
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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