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      Genus Viburnum: Therapeutic Potentialities and Agro-Food-Pharma Applications


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          The genus Viburnum (Adoxaceae, Dipsacales) is of scientific interest due to the chemical components and diverse biological activities found across species of the genus, which includes more than 230 species of evergreen, semievergreen, or deciduous shrubs and small trees. Although frequently used as an ornament, the Viburnum species show biological properties with health-promoting effects. Fruits, flowers, and barks of certain species are used for pharmaceutical purposes or as cooking ingredients, hence containing biochemical compounds with health-promoting activity such are carotenoids, polyphenols, and flavonoids. However, its taxonomical determination is difficult, due to its wide distribution and frequent hybridizations; therefore, an objective classification would allow us to understand its biological activity based on its phytochemical components. More than sixty phytochemical compounds have been reported, where vibsanin-type diterpenes and their derivatives are the most prevalent. Leaves and twigs of V. dilatatum contain the largest number of phytochemicals among the genus. Through preclinical evidence, this study provides insight regarding antioxidant, antibacterial, anti-inflammatory, cytotoxic, and anticancer activities of genus Viburnum.

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          Most cited references218

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          An update of the Angiosperm Phylogeny Group classification for the orders and families of flowering plants: APG IV

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            Antioxidant activity and phenolic compounds in 32 selected herbs

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              Ecological status and traditional knowledge of medicinal plants in Kedarnath Wildlife Sanctuary of Garhwal Himalaya, India

              Background Himalayan forests are the most important source of medicinal plants and with useful species for the local people. Kedarnath Wildlife Sanctuary (KWLS) is situated in the interior part of the Garhwal Himalayan region. The presented study was carried out in Madhmeshwar area of KWLS for the ecological status of medicinal plants and further focused on the ethnomedicinal uses of these plants in the study area. Methods Ecological information about ethnomedicinal plants were collected using random quadrats in a random sampling technique along an altitudinal gradient in the KWLS. Information on medicinal properties of plants encountered in the present study was generated by questionnaire survey and was also compared with relevant literature. Results A total of 152 medicinally important plant species were reported, in which 103 were found herbs, 32 shrubs and 17 were tree species which represented 123 genera of 61 families. A total of 18 plant species fell into the rare, endangered (critically endangered) and vulnerable status categories. Conclusion The present study documented the traditional uses of medicinal plants, their ecological status and importance of these plants in the largest protected area of Garhwal Himalaya. This study can serve as baseline information on medicinal plants and could be helpful to further strengthen the conservation of this important resource.

                Author and article information

                Oxid Med Cell Longev
                Oxid Med Cell Longev
                Oxidative Medicine and Cellular Longevity
                16 July 2021
                : 2021
                : 3095514
                1Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
                2Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique 1110939, Chile
                3Centro de Investigación de Estudios Avanzados del Maule, Vicerrectoría de Investigación y Postgrado, Universidad Católica del Maule, Chile
                4Faculty of Medicine, Department of Pharmacy, University of Niš, Ave. Zorana Djindjica 81, 18000 Nis, Serbia
                5Departament of Pharmaceutical Sciences, State University of Ponta Grossa, 84030900, Ponta Grossa, Paraná, Brazil
                6Department of Plant Sciences, Quaid-i-Azam University, Islamabad, Pakistan
                7Pakistan Academy of Sciences, Islamabad, Pakistan
                8Department of Pathology, Lady Reading Hospital Medical Teaching Institution, Peshawar (25000), KP, Pakistan
                9Institute of Field and Vegetable Crops, National Institute of the Republic of Serbia, Alternative Crops and Organic Production Department, Maksima Gorkog 30, 21000 Novi Sad, Serbia
                10Faculty of Agriculture, Department of Field and Vegetable Crops, University of Novi Sad, Trg Dositeja Obradovića 8, 21000 Novi Sad, Serbia
                11Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università Degli Studi di Milano, Via Beldiletto 1, 20142 Milan, Italy
                12Dipartimento di Scienze Agrarie e Ambientali, Via Celoria 2, 20133 Milan, Italy
                13Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México 04510, Mexico
                14Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile
                15Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco 4811230, Chile
                16Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
                Author notes

                Academic Editor: German Gil

                Author information
                Copyright © 2021 Javad Sharifi-Rad et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                : 8 May 2021
                : 8 June 2021
                : 11 June 2021
                Review Article

                Molecular medicine
                Molecular medicine


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