Genetic Lineage Tracing of Nonmyocyte Population by Dual Recombinases

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Abstract

<p class="first" id="d5083093e263">Whether the adult mammalian heart harbors cardiac stem cells for regeneration of cardiomyocytes is an important yet contentious topic in the field of cardiovascular regeneration. The putative myocyte stem cell populations recognized without specific cell markers, such as the cardiosphere-derived cells, or with markers such as Sca1+, Bmi1+, Isl1+, or Abcg2+ cardiac stem cells have been reported. Moreover, it remains unclear whether putative cardiac stem cells with unknown or unidentified markers exist and give rise to de novo cardiomyocytes in the adult heart. </p>

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Journal

Title: Circulation

Abbreviated Title: Circulation

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Print): 0009-7322

ISSN (Electronic): 1524-4539

Publication date Created: August 21 2018

Publication date (Print): August 21 2018

Volume: 138

Issue: 8

Pages: 793-805

Affiliations

[1 ]The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, and Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, China (Yan Li, L.H., X.H., H.Z., S.Z., W.P., X.T., Yi Li, Q.L., W.Y., L.Z., X.L., K.L., J.T., H.Z., B.Z.)

[2 ]Cardiovascular Division, British Heart Foundation Centre, King’s College London, United Kingdom (S.I.B. Q.X.)

[3 ]Key Laboratory of Regenerative Medicine of Ministry of Education, Jinan University, China (X.T., D.C., B.Z.)

[4 ]Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, Faculty of Medicine, University of Muenster, Germany (A.H.R.)

[5 ]Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China (K.O.L.).

[6 ]School of Life Science and Technology, ShanghaiTech University, China (B.Z.)

Article

DOI: 10.1161/CIRCULATIONAHA.118.034250

PubMed ID: 29700121

SO-VID: f70c854e-4854-45af-8ef8-933d420e58f9

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