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      The effects of repeated nitroglycerin administrations in rats; modeling migraine-related endpoints and chronification.

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          Abstract

          Rodent models typically use a single nitroglycerin injection to induce migraine, yet migraine in clinical populations presents as recurrent episodes. Further, these models quantify behavioral endpoints that do not align with the clinical features of episodic migraine or migraine chronification and therefore may limit translational relevance.

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          Author and article information

          Journal
          J. Neurosci. Methods
          Journal of neuroscience methods
          Elsevier BV
          1872-678X
          0165-0270
          Jun 01 2017
          : 284
          Affiliations
          [1 ] Department of Psychology, University of Mississippi, 207 Peabody Building, University, MS 38677, USA. Electronic address: hmharris@go.olemiss.edu.
          [2 ] Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA. Electronic address: jmc69554@uga.edu.
          [3 ] Department of Psychology, University of Mississippi, 207 Peabody Building, University, MS 38677, USA. Electronic address: jrblack@go.olemiss.edu.
          [4 ] Department of Psychology, University of Mississippi, 207 Peabody Building, University, MS 38677, USA. Electronic address: tasmithe@olemiss.edu.
          [5 ] Department of Psychology, University of Mississippi, 207 Peabody Building, University, MS 38677, USA; Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA. Electronic address: pysufka@olemiss.edu.
          Article
          S0165-0270(17)30109-7
          10.1016/j.jneumeth.2017.04.010
          28442295

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