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      In Situ Synthesis of Magnetic Field-Responsive Hemicellulose Hydrogels for Drug Delivery

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          Abstract

          A one-pot synthetic methodology for fabricating stimuli-responsive hemicellulose-based hydrogels was developed that consists of the in situ formation of magnetic iron oxide (Fe 3O 4) nanoparticles during the covalent cross-linking of O-acetyl-galactoglucomannan (AcGGM). The Fe 3O 4 nanoparticle content controlled the thermal stability, macrostructure, swelling behavior, and magnetization of the hybrid hydrogels. In addition, the magnetic field-responsive hemicellulose hydrogels (MFRHHs) exhibited excellent adsorption and controlled release profiles with bovine serum albumin (BSA) as the model drug. Therefore, the MFRHHs have great potential to be utilized in the biomedical field for tissue engineering applications, controlled drug delivery, and magnetically assisted bioseparation. Magnetic field-responsive hemicellulose hydrogels, prepared using a straightforward one-step process, expand the applications of biomass-derived polysaccharides by combining the renewability of hemicellulose and the magnetism of Fe 3O 4 nanoparticles.

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          Most cited references39

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          Thiol-yne ‘click’/coupling chemistry and recent applications in polymer and materials synthesis and modification

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            Preparation and adsorption property of xylan/poly(acrylic acid) magnetic nanocomposite hydrogel adsorbent.

            Adsorbents based on natural polysaccharides have attracted increasing interest because of their low-cost and biodegradability, particularly, polysaccharide-based nanocomposite adsorbents. In this study the xylan/poly(acrylic acid) magnetic nanocomposite hydrogel adsorbent was prepared from wheat straw xylan and Fe3O4 nanoparticles, and its adsorption property was studied on methylene blue removal. The prepared hydrogel adsorbent had a semi-interpenetrating network structure and exhibited a macro-porous structure with interconnected porous channels. Super-paramagnetic characteristic behavior was observed from magnetic analysis using a vibrating sample magnetometer. The optimum condition for methylene blue adsorption on the adsorbent was found at pH 8 with an adsorbent dosage of 3g/L and an initial concentration of 400mg/L, and the removal percentage reached above 90%. The adsorption isotherm of methylene blue on the prepared hydrogel adsorbent was fitted to the Langmuir model, and the pseudo-second-order kinetic model could describe the adsorption process. All obtained results indicated that the prepared hydrogel adsorbent is promising for water treatment applications.
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              Hemicellulose-based pH-sensitive and biodegradable hydrogel for controlled drug delivery.

              Hydrogels based on hemicellulose of wheat straw were prepared as a novel carrier for controlled drug delivery. The chemical structure and morphology of the hydrogels were characterised using FT-IR and SEM, respectively. The swelling ratios of the hydrogels were determined, and the results showed that the hydrogels were pH-responsive. The swelling kinetics of the hydrogels followed a Fickian diffusion process in media with a pH of 1.5, and water uptake was controlled collaboratively by hydrogel relaxation and water diffusion in media with pH values of 7.4 and 10.0. The degradation test of the hydrogels was conducted under simulated physiological conditions, and both hemicellulose content and the crosslinking density of the hydrogels were major factors that affected the biodegradability of the hemicellulose-based hydrogels. A comparison of the in vitro release of acetylsalicylic acid and theophylline indicated that the drug release was controlled both by the hydrogel and by the intrinsic character of the drug. According to the results presented here, hemicellulose-based hydrogels can be used in biomedical fields, especially for controlled drug release.
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                Author and article information

                Journal
                Biomacromolecules
                Biomacromolecules
                bm
                bomaf6
                Biomacromolecules
                American Chemical Society
                1525-7797
                1526-4602
                21 July 2015
                10 August 2015
                : 16
                : 8
                : 2522-2528
                Affiliations
                []Fiber and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology (KTH) , Teknikringen 56-58 SE-100 44, Stockholm, Sweden
                []College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University , 610065, Chengdu, China
                Author notes
                [* ]Tel.:+46-8-790 8274. Fax: +46-8-20 8477. E-mail: aila@ 123456kth.se .
                Article
                10.1021/acs.biomac.5b00801
                4535706
                26196600
                f71351e3-7b03-4926-98c4-ad75b776e165
                Copyright © 2015 American Chemical Society

                This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

                History
                : 16 June 2015
                : 20 July 2015
                Categories
                Article
                Custom metadata
                bm5b00801
                bm-2015-00801n

                Biochemistry
                Biochemistry

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