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      Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescence in situ hybridization.

      The Japanese journal of human genetics

      genetics, Cells, Cultured, Mixed Function Oxygenases, Microscopy, Fluorescence, Lymphocytes, In Situ Hybridization, Humans, Cytochrome P-450 Enzyme System, Cytochrome P-450 CYP3A, Chromosomes, Human, Pair 7, Chromosome Mapping, Chromosome Banding

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          Abstract

          We have used a full length cDNA clone (2.2 kb) for the human cytochrome P-450 nifedipine oxidase (CYP3A4) enzyme as a probe to determine its chromosome localization by fluorescence in situ hybridization. CYP3A4 was mapped on R-banded human prometaphase chromosomes, and the precise localization of CYP3A4 on chromosome 7 was further confirmed by a delineation of G-banded pattern on the same prometaphase chromosomes through a combination of UV-filter. We assigned CYP3A4 to chromosome 7 at q22.1.

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          Journal
          10.1007/BF01899734
          1391968

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