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      BRENDA, the enzyme database: updates and major new developments

      Nucleic Acids Research

      Oxford University Press (OUP)

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          Abstract

          BRENDA (BRaunschweig ENzyme DAtabase) represents a comprehensive collection of enzyme and metabolic information, based on primary literature. The database contains data from at least 83,000 different enzymes from 9800 different organisms, classified in approximately 4200 EC numbers. BRENDA includes biochemical and molecular information on classification and nomenclature, reaction and specificity, functional parameters, occurrence, enzyme structure, application, engineering, stability, disease, isolation and preparation, links and literature references. The data are extracted and evaluated from approximately 46,000 references, which are linked to PubMed as long as the reference is cited in PubMed. In the past year BRENDA has undergone major changes including a large increase in updating speed with >50% of all data updated in 2002 or in the first half of 2003, the development of a new EC-tree browser, a taxonomy-tree browser, a chemical substructure search engine for ligand structure, the development of controlled vocabulary, an ontology for some information fields and a thesaurus for ligand names. The database is accessible free of charge to the academic community at http://www.brenda. uni-koeln.de.

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          Author and article information

          Journal
          Nucleic Acids Research
          Nucleic Acids Research
          Oxford University Press (OUP)
          1362-4962
          January 01 2004
          January 01 2004
          : 32
          : 90001
          : 431D-433
          Article
          10.1093/nar/gkh081
          308815
          14681450
          © 2004

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