BRENDA (BRaunschweig ENzyme DAtabase) represents a comprehensive collection of enzyme
and metabolic information, based on primary literature. The database contains data
from at least 83,000 different enzymes from 9800 different organisms, classified in
approximately 4200 EC numbers. BRENDA includes biochemical and molecular information
on classification and nomenclature, reaction and specificity, functional parameters,
occurrence, enzyme structure, application, engineering, stability, disease, isolation
and preparation, links and literature references. The data are extracted and evaluated
from approximately 46,000 references, which are linked to PubMed as long as the reference
is cited in PubMed. In the past year BRENDA has undergone major changes including
a large increase in updating speed with >50% of all data updated in 2002 or in the
first half of 2003, the development of a new EC-tree browser, a taxonomy-tree browser,
a chemical substructure search engine for ligand structure, the development of controlled
vocabulary, an ontology for some information fields and a thesaurus for ligand names.
The database is accessible free of charge to the academic community at http://www.brenda.