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      Renal Function and Hemodynamics during Treatment with Enalapril in Primary Hypertension

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          Abstract

          Thirty-nine hypertensive patients were entered into a randomized, double-blind protocol to assess the effects of enalapril (10–20 mg b.i.d.), or combined enalapril (10–20 mg b.i.d.) and hydrochlorothiazide (25–50 mg b.i.d.) therapy on renal function and hemodynamics. Enalapril, either alone or in combination with hydrochlorothiazide, effectively controlled blood pressure. In patients with an initial inulin clearance ≤ 80 ml/min/1.73 m<sup>2</sup>, inulin and p-aminohippurate clearances were markedly improved toward normal following either drug therapy. The filtration fraction was either unchanged (monotherapy) or increased (combination therapy), suggesting a direct glomerular effect of angiotensin-converting enzyme inhibition. Renal vascular resistance was decreased in all patients. These observations suggest that enalapril, either alone or in combination with a diuretic, has the potential to reverse renal function abnormalities encountered in the hypertensive state.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-4387-3
          978-3-318-01793-9
          1660-8151
          2235-3186
          1986
          1986
          05 December 2008
          : 44
          : Suppl 1
          : 83-86
          Affiliations
          Medical Service, Harry S. Truman Memorial Veterans Hospital, and Department of Medicine, University of Missouri School of Medicine, Columbia, Mo., USA
          Article
          184053 Nephron 1986;44:83–86
          10.1159/000184053
          3018603
          © 1986 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Modern Therapeutic Approaches in Renovascular Hypertension: Antihypertensive Drugs

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