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      Biosensors and sensors for dopamine detection

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          Functional nucleic acid sensors.

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            Aptamer–field-effect transistors overcome Debye length limitations for small-molecule sensing

            Detection of analytes with field-effect transistors bearing ligand-specific receptors is fundamentally limited by the shielding created by the electrical double layer (the "Debye length" limitation). We detected small molecules under physiological high ionic-strength conditions by modifying printed ultrathin metal-oxide field-effect transistor arrays with deoxyribonucleotide aptamers selected to bind their targets adaptively. Target-induced conformational changes of negatively charged aptamer phosphodiester backbones in close proximity to semiconductor channels gated conductance in physiological buffers, resulting in highly sensitive detection. Sensing of charged and electroneutral targets (serotonin, dopamine, glucose, and sphinghosine-1-phosphate) was enabled by specifically isolated aptameric stem-loop receptors.
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              Oxidant-induced dopamine polymerization for multifunctional coatings

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                Author and article information

                Contributors
                Journal
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                Wiley
                2688-268X
                2688-268X
                February 2021
                September 13 2020
                February 2021
                : 2
                : 1
                : 20200102
                Affiliations
                [1 ]Hubei Key Laboratory of Edible Wild Plants Conservation and Utilization Hubei Normal University Huangshi China
                [2 ]Department of Chemistry and Waterloo Institute for Nanotechnology University of Waterloo Waterloo Canada
                Article
                10.1002/VIW.20200102
                34766163
                f7609c8c-49fa-456b-bfc8-5fad5761ed95
                © 2021

                http://creativecommons.org/licenses/by/4.0/

                http://doi.wiley.com/10.1002/tdm_license_1.1

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