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      Obesity and lung inflammation.

      1
      Journal of applied physiology (Bethesda, Md. : 1985)
      American Physiological Society

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          Abstract

          The prevalence of obesity has increased dramatically worldwide, predisposing individuals to an increased risk of morbidity and mortality due to cardiovascular disease and type 2 diabetes. Less recognized is the fact that obesity may play a significant role in the pathogenesis of pulmonary diseases through mechanisms that may involve proinflammatory mediators produced in adipose tissue that contribute to a low-grade state of systemic inflammation. In animal models, inflammatory responses in the lung have been shown to influence the production of the adipocytokines, leptin and adiponectin, cytokines, acute phase proteins, and other mediators produced by adipose tissue that may participate in immune responses of the lung. An increased adipose tissue mass may also influence susceptibility to pulmonary infections, enhance pulmonary inflammation associated with environmental exposures, and exacerbate airway obstruction in preexisting lung disease. An increased understanding of the mechanisms by which obesity influences pulmonary inflammation may facilitate the development of novel therapeutic interventions for the treatment of lung disease.

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          Author and article information

          Journal
          J Appl Physiol (1985)
          Journal of applied physiology (Bethesda, Md. : 1985)
          American Physiological Society
          1522-1601
          0161-7567
          Mar 2010
          : 108
          : 3
          Affiliations
          [1 ] Department of Environmental Health Sciences, School of Public Health, SPH IA Tower, 109 S. Observatory St., Ann Arbor, MI 48109-2029, USA. pmancuso@umich.edu
          Article
          00781.2009
          10.1152/japplphysiol.00781.2009
          2838639
          19875709
          f7776fdb-8946-4f40-a745-7b22332c77ff
          History

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