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      Serum Insulin-Like Growth Factor 1 Level and Nutritional Assessment in Nondialytic Patients with Chronic Renal Failure

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          Abstract

          Aim: In order to understand the nutritional status of nondialytic patients with chronic renal failure (CRF), nutritional assessment was made in 20 nondialytic patients (15 males and 5 females; mean age 43.7 ± 15.1 years). Methods: Twenty CRF inpatients were selected for nutritional assessment, and 20 normal subjects served as controls. The serum insulin-like growth factor 1 (IGF-1) concentration was measured by ELISA. Serum albumin, prealbumin, and transferrin levels were also determined. Results: The mean IGF-I and transferrin levels in the CRF patients were significantly lower than those in normal subjects (IGF-1: 176.2 ± 92.5 µg/l vs. 266.7 ± 101.7 µg/l, p < 0.01; transferrin: 2.57 ± 0.58 g/l vs. 3.18 ± 0.27 g/l, p < 0.05). The IGF-1 levels in 7 patients with a serum albumin concentration <40.0 g/l were significantly lower than those in 13 patients with a serum albumin concentration >40.0 g/l (95.6 ± 42.4 µg/l vs. 219.6 ± 82.7 µg/l, p < 0.01). The IGF-1 levels in cases treated with α-ketoacid were higher than in those without α-ketoacid treatment. The IGF-1 levels were positively correlated with creatinine clearance (r = 0.7066, p < 0.01) and serum transferrin concentration (r = 0.5347, p < 0.05). Conclusions: The fact that serum IGF-1 was correlated with serum transferrin and creatinine clearance suggests that IGF-1 may be a good indicator for assessing the nutritional status of CRF patients. The serum IGF-1 level in CRF patients is probably lower than that in normal subjects and could be improved by nutritional therapy.

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          Author and article information

          Journal
          KBR
          Kidney Blood Press Res
          10.1159/issn.1420-4096
          Kidney and Blood Pressure Research
          S. Karger AG
          1420-4096
          1423-0143
          2002
          2002
          03 July 2002
          : 25
          : 2
          : 116-119
          Affiliations
          Departments of Nephrology, aChina-Japan Friendship Hospital, Beijing, and bBeijing Union Hospital, Beijing, People’s Republic of China; cDivision of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
          Article
          63519 Kidney Blood Press Res 2002;25:116–119
          10.1159/000063519
          12077495
          © 2002 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Tables: 3, References: 16, Pages: 4
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/63519
          Categories
          Sixth Asian Nephrology Forum

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