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      Nogo Receptor 1 Confines a Disinhibitory Microcircuit to the Critical Period in Visual Cortex

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          Abstract

          A characteristic of the developing mammalian visual system is a brief interval of plasticity, termed the “critical period,” when the circuitry of primary visual cortex is most sensitive to perturbation of visual experience. Depriving one eye of vision (monocular deprivation [MD]) during the critical period alters ocular dominance (OD) by shifting the responsiveness of neurons in visual cortex to favor the nondeprived eye. A disinhibitory microcircuit involving parvalbumin-expressing (PV) interneurons initiates this OD plasticity. The gene encoding the neuronal nogo-66-receptor 1 ( ngr1/rtn4r) is required to close the critical period. Here we combined mouse genetics, electrophysiology, and circuit mapping with laser-scanning photostimulation to investigate whether disinhibition is confined to the critical period by ngr1. We demonstrate that ngr1 mutant mice retain plasticity characteristic of the critical period as adults, and that ngr1 operates within PV interneurons to restrict the loss of intracortical excitatory synaptic input following MD in adult mice, and this disinhibition induces a “lower PV network configuration” in both critical-period wild-type mice and adult ngr1 −/− mice. We propose that ngr1 limits disinhibition to close the critical period for OD plasticity and that a decrease in PV expression levels reports the diminished recent cumulative activity of these interneurons.

          SIGNIFICANCE STATEMENT Life experience refines brain circuits throughout development during specified critical periods. Abnormal experience during these critical periods can yield enduring maladaptive changes in neural circuits that impair brain function. In the developing visual system, visual deprivation early in life can result in amblyopia (lazy-eye), a prevalent childhood disorder comprising permanent deficits in spatial vision. Here we identify that the nogo-66 receptor 1 gene restricts an early and essential step in OD plasticity to the critical period. These findings link the emerging circuit-level description of OD plasticity to the genetic regulation of the critical period. Understanding how plasticity is confined to critical periods may provide clues how to better treat amblyopia.

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          Author and article information

          Journal
          J Neurosci
          J. Neurosci
          jneuro
          jneurosci
          J. Neurosci
          The Journal of Neuroscience
          Society for Neuroscience
          0270-6474
          1529-2401
          26 October 2016
          26 April 2017
          : 36
          : 43
          : 11006-11012
          Affiliations
          1Developmental Neuroscience Program, Saban Research Institute, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California 90027, and
          2Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, California 92697
          Author notes
          Correspondence should be addressed to either of the following: Dr. Xiangmin Xu, Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697, xiangmix@ 123456uci.edu ; or Dr. Aaron W. McGee, Department of Anatomical Sciences & Neurobiology, University of Louisville, Louisville, KY 40292. aaron.mcgee@ 123456louisville.edu

          Author contributions: X.X. and A.W.M. designed research; C.-E.S., T.I., and C.N. performed research; X.X. and A.W.M. contributed unpublished reagents/analytic tools; C.-E.S., T.I., C.N., X.X., and A.W.M. analyzed data; C.-E.S., X.X., and A.W.M. wrote the paper.

          *C.-E.S. and T.I. contributed equally to this work.

          A.W. McGee's present address: Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY 40202.

          Article
          PMC5098837 PMC5098837 5098837 0935-16
          10.1523/JNEUROSCI.0935-16.2016
          5098837
          27798181
          Copyright © 2016 the authors 0270-6474/16/3611006-07$15.00/0
          Categories
          Research Articles
          Development/Plasticity/Repair

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