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Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization.
Channa N Jayasena ,
Ali Abbara ,
Alexander N Comninos ,
Gurjinder M K Nijher ,
Georgios Christopoulos ,
Shakunthala Narayanaswamy ,
Chioma Izzi-Engbeaya ,
Mathini Sridharan ,
Alexina J Mason ,
Jane Warwick ,
Deborah Ashby ,
Mohammad A Ghatei ,
Stephen R Bloom ,
Anna Carby ,
Geoffrey H Trew ,
Waljit S Dhillo
Aug 2014
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Abstract
Patients with mutations that inactivate kisspeptin signaling are infertile. Kisspeptin-54, the major circulating isoform of kisspeptin in humans, potently stimulates reproductive hormone secretion in humans. Animal studies suggest that kisspeptin is involved in generation of the luteinizing hormone surge, which is required for ovulation; therefore, we hypothesized that kisspeptin-54 could be used to trigger egg maturation in women undergoing in vitro fertilization therapy.