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      Conductance and selectivity properties of a substate of the rabbit sarcoplasmic reticulum channel

      Biophysical Journal
      Elsevier BV

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          Abstract

          In this paper I describe the occurrence and properties of a subconductance state of the cation-selective channel of the sarcoplasmic reticulum. The substate conductance is 60% of the major state conductance in every salt solution examined. When single channel conductance is plotted vs. ion concentration (for potassium or thallium salt solutions) the Michaelis-Menten constant is nearly the same for both conductance states, while the maximum conductance is reduced for the subconductance state. Both conductance states show anomalous conductance behavior in mixed potassium-thallium solutions that may be modeled in the same way. These results indicate that the ionic selectivity of the channel is the same for both open states.

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          Author and article information

          Journal
          Biophysical Journal
          Biophysical Journal
          Elsevier BV
          00063495
          April 1985
          April 1985
          : 47
          : 4
          : 573-576
          Article
          10.1016/S0006-3495(85)83953-9
          1435138
          2580571
          f7a0d6f0-61d8-4711-85a3-27959ef8c7ee
          © 1985

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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