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Effective healing of diabetic skin wounds by using nonviral gene therapy based on minicircle vascular endothelial growth factor DNA and a cationic dendrimer.
Min J Kwon
1 ,
Songhie An ,
Sunghyun Choi ,
Kihoon Nam ,
Hye S Jung ,
Chang S Yoon ,
Jung H Ko ,
Hye J Jun ,
Tae K Kim ,
Soo J Jung ,
Jeong H Park ,
Yan Lee ,
Jong-Sang Park
Apr 2012
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Abstract
The development of an efficient method to improve the wound healing process is urgently required for diabetic patients suffering a threat of limb amputations. Various growth factors have been proposed for treatment; however, more research still has to be carried out to maintain their curative effect. In the present study, we describe a simple nonviral gene therapy method for improving wound healing.