Perceptions of plague in eighteenth‐century Europe†

The second plague pandemic, caused by Yersinia pestis, devastated Europe and the nearby regions between the 14th and 18th centuries AD. Here we analyse human remains from ten European archaeological sites spanning this period and reconstruct 34 ancient Y. pestis genomes. Our data support an initial entry of the bacterium through eastern Europe, the absence of genetic diversity during the Black Death, and low within-outbreak diversity thereafter. Analysis of post-Black Death genomes shows the diversification of a Y. pestis lineage into multiple genetically distinct clades that may have given rise to more than one disease reservoir in, or close to, Europe. In addition, we show the loss of a genomic region that includes virulence-related genes in strains associated with late stages of the pandemic. The deletion was also identified in genomes connected with the first plague pandemic (541–750 AD), suggesting a comparable evolutionary trajectory of Y. pestis during both events.

This article provides an overview of recent literature on plagues and other lethal epidemics, covering the period from late Antiquity to ca. 1800. We analyze the main environmental and institutional factors that shaped both the way in which a plague originated and spread and its overall demographic and socioeconomic consequences. We clarify how the same pathogen shows historically different epidemiological characteristics, and how apparently similar epidemics could have deeply different consequences. We discuss current debates about the socioeconomic consequences of the Black Death and other plagues. We conclude with historical lessons to understand modern “plagues.”