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      BNP and NT-proBNP as Diagnostic Biomarkers for Cardiac Dysfunction in Both Clinical and Forensic Medicine

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          Abstract

          Currently, brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are widely used as diagnostic biomarkers for heart failure (HF) and cardiac dysfunction in clinical medicine. They are also used as postmortem biomarkers reflecting cardiac function of the deceased before death in forensic medicine. Several previous studies have reviewed BNP and NT-proBNP in clinical medicine, however, few articles have reviewed their application in forensic medicine. The present article reviews the biological features, the research and application status, and the future research prospects of BNP and NT-proBNP in both clinical medicine and forensic medicine, thereby providing valuable assistance for clinicians and forensic pathologists.

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          ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM).

          Kenneth Dickstein, Alain Cohen-Solal, Gerasimos Filippatos … (2008)
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            Natriuretic peptides.

            E. R. Levin, D Gardner, W Samson (1998)
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              Natriuretic peptides.

              Lori B Daniels, Alan Maisel (2007)
              Natriuretic peptides (NPs) are released from the heart in response to pressure and volume overload. B-type natriuretic peptide (BNP) and N-terminal-proBNP have become important diagnostic tools for assessing patients who present acutely with dyspnea. The NP level reflects a compilation of systolic and diastolic function as well as right ventricular and valvular function. Studies suggest that using NPs in the emergency department can reduce the consumption of hospital resources and can lower costs by either eliminating the need for other, more expensive tests or by establishing an alternative diagnosis that does not require hospital stay. Caveats such as body mass index and renal function must be taken into account when analyzing NP levels. Natriuretic peptide levels have important prognostic value in multiple clinical settings, including in patients with stable coronary artery disease and with acute coronary syndromes. In patients with decompensated heart failure due to volume overload, a treatment-induced drop in wedge pressure is often accompanied by a rapid drop in NP levels. Knowing a patient's NP levels might thus assist with hemodynamic assessment and subsequent treatment titration. Monitoring NP levels in the outpatient setting might also improve patient care and outcomes.
              Article 0 comments Cited 228 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Int J Mol Sci
                Journal ID (iso-abbrev): Int J Mol Sci
                Journal ID (publisher-id): ijms
                Title: International Journal of Molecular Sciences
                Publisher: MDPI
                ISSN (Electronic): 1422-0067
                Publication date (Electronic): 12 April 2019
                Publication date Collection: April 2019
                Volume: 20
                Issue: 8
                Electronic Location Identifier: 1820
                Affiliations
                Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110122, China; zpcao@ 123456cmu.edu.cn (Z.C.); jia214@ 123456hotmail.com (Y.J.)
                Author notes
                [* ]Correspondence: zhu1127@ 123456hotmail.com ; Tel.: +86-24-3193-9433
                Author information
                https://orcid.org/0000-0002-4275-0788
                https://orcid.org/0000-0001-6083-4187
                Article
                Publisher ID: ijms-20-01820
                DOI: 10.3390/ijms20081820
                PMC ID: 6515513
                PubMed ID: 31013779
                SO-VID: f7c85433-9bc9-477c-bb4b-04752a236b52
                Copyright © © 2019 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 14 March 2019
                Date accepted : 11 April 2019
                Categories
                Subject: Review

                ScienceOpen disciplines: Molecular biology
                Keywords: bnp,nt-probnp,heart failure,cardiac dysfunction,forensic medicine,postmortem biochemistry
                Data availability:
                ScienceOpen disciplines: Molecular biology
                Keywords: bnp, nt-probnp, heart failure, cardiac dysfunction, forensic medicine, postmortem biochemistry

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