Actinomycin D Blocks the Hepatic Functional Albumin mRNA Increase in Aminonucleoside-Nephrotic Rats

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Abstract

Hepatic functional albumin-mRNA was measured in the following groups of rats: (a) puromycin aminonucleoside (PAN)-nephrotic rats, (b) PAN-nephrotic rats treated with actinomycin D prior to sacrifice, (c) control rats, and (d) control rats treated with actinomycin D. Albumin mRNA was translated in an mRNA-dependent cell-free system from rabbit reticulocyte lysate. Albumin-mRNA increased about 2-fold in PAN-nephrotic rats. This increase was abolished in vivo in PAN-nephrotic rats treated with actinomycin D. Albumin mRNA was not significantly modified in control rats treated with actinomycin D. These data suggest that the increased level of hepatic functional albumin mRNA observed in PAN-nephrotic rats in vivo was due mainly to the increased rate of albumin gene transcription.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1991

Publication date (Print): 1991

Publication date (Electronic): 11 December 2008

Volume: 59

Issue: 4

Pages: 648-650

Affiliations

Departamento de Bioquímica, Instituto Nacional de la Nutrición ‘Salvador Zubirán’, Mexico, Mexico

Article

Publisher ID: 186659 Other ID: Nephron 1991;59:648–650

DOI: 10.1159/000186659

PubMed ID: 1766506

SO-VID: f7cc112b-9e06-4598-a7c4-ac14ea305eff

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Actinomycin D Blocks the Hepatic Functional Albumin mRNA Increase in Aminonucleoside-Nephrotic Rats

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Karger: Nephrology

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